Sökning: "Repressive"

Visar resultat 6 - 10 av 103 avhandlingar innehållade ordet Repressive.

  1. 6. Modulation of nuclear receptor function by interacting proteins

    Författare :Waffa Osman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Nuclear receptors are a family of transcription factors involved in many biological processes. They represent key potentials as therapeutic targets for several clinical conditions such as diabetes, obesity, cardiovascular disease and cancer, because their activity is modulated by small molecules. LÄS MER

  3. 7. Fission yeast mediator complex and its role in transcriptional regulation

    Författare :Olga Khorosjutina; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mediator is an evolutionary conserved co-activator complex that regulates transcription of protein encoding genes in eukaryotes. This multiprotein complex was first identified in budding yeast and shown to be indispensable for RNA polymerase II (pol II) dependent transcription. LÄS MER

  4. 8. Regulation of tartrate-resistant purple acid phosphatase by proteolytic processing in rat

    Författare :Jenny Ljusberg-Sjölander; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Purple acid phosphatase; enzyme catalysis; proteolytic processing;

    Sammanfattning : Purple acid phosphatase (PAP) is an iron-containing binuclear acid metallohydrolase with a characteristic purple colour, also referred to as tartrate-resistant acid phosphatase (TRAP), uteroferrin or type 5 acid phosphatase. PAP is highly expressed in osteoclasts and has a role in bone resorption. LÄS MER

  5. 9. Long Noncoding RNA Mediated Regulation of Imprinted Genes

    Författare :Faizaan Mohammad; Chandrasekhar Kanduri; Kristian Helin; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Genomic imprinting; noncoding RNA; epigenetics; chromatin; DNA methylation; Developmental biology; Utvecklingsbiologi; Molecular biology; Molekylärbiologi; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Sammanfattning : Genomic imprinting is an epigenetic phenomenon that causes a subset of mammalian genes to be expressed from only one allele in a parent-of-origin manner. The defects in the imprinting regulation result in disorders that affect development, growth and metabolism. LÄS MER

  7. 10. Clinical studies on the borderline concept with special reference to suicidal behavior

    Författare :Gunnar Kullgren; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; borderline;

    Sammanfattning : The diagnostic concept of borderline personality has had various meanings throughout the last decades. From current clinical practice and research two principally different concepts have emerged: The syndrome concept of borderline personality disorder ( BPD ) as identified by the DSM-III or the Diagnostic Interview for Borderline (DIB) and the psychodynamic concept of borderline personality organization (BPO) as defined from the structural Interview (SI) by Otto Kernberg. LÄS MER