Sökning: "Repressive"

Visar resultat 11 - 15 av 103 avhandlingar innehållade ordet Repressive.

  1. 11. Tumour Survival Signals and Epigenetic Gene Silencing in Multiple Myeloma : Implications for Biology and Therapy

    Författare :Charlotte Fristedt Duvefelt; Helena Jernberg-Wiklund; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Multiple myeloma; Polycomb; apoptosis; cIAP2; IAP-inbibitors; proteasome inhibitors; LBH589; PPP; DZNep;

    Sammanfattning : This thesis is focused on multiple myeloma (MM), a haematological malignancy that still remains incurable. The pathogenesis of MM is not fully understood and there is a large intra-tumour and interclonal genetic variation in MM patients. LÄS MER

  3. 12. FET fusion oncoproteins in sarcoma tumorigenesis - lnteractions with the SWI/SNF chromatin remodeling complex and epigenetic effects

    Författare :Malin Lindén; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ewing sarcoma; Epigenetics; FET fusion oncoproteins; Myxoid liposarcoma; Proteomics; SWI SNF BAF chromatin remodeling complex;

    Sammanfattning : The FET family of fusion oncoproteins containing the N-terminal of either FUS, EWSR1 or TAF15 together with a transcription factor partner is the characteristic oncogenic driver of more than 20 types of sarcoma and leukemia, including myxoid liposarcoma and Ewing sarcoma. The FET oncoproteins are thought to function as aberrant transcription factors, however, the exact oncogenic mechanism remains to be elucidated. LÄS MER

  4. 13. Moving thresholds : body narratives within the vicinity of gym and fitness culture

    Författare :Greta Bladh; Jesper Andreasson; Linda Sandberg; Åsa Bäckström; Umeå universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; gender; gym and fitness; thresholds; body narrative; vulnerable inclusiveness; genusvetenskap; gender studies; Sociology; sociologi;

    Sammanfattning : This thesis investigates thresholds that impede bodies from moving to, and within, gym and fitness sites. Thresholds are here understood as gendered social constructs and norms, which direct bodies in certain ways, and thus circumscribing potential movements and capabilities. LÄS MER

  5. 14. Confinement and Caring - On sociomaterial practices in secured institutions for youths

    Författare :Kajsa Nolbeck; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Institutional youth care; Care environment; Sociomateriality; Erving Goffman; Quantitative methods; Ethnography; Photovoice; Focus group discussions;

    Sammanfattning : In special youth homes run by the Swedish National Board of Institutional Care, youths are placed because of involuntary care or a verdict. The legal regulations and conflicting requirements of care, security, and children’s rights place high demands on these institutions’ care environment. LÄS MER

  7. 15. Ideologins apparatur : reproduktionsperspektiv på kyrka och skola i 1600- och 1700-talens Sverige

    Författare :Tobias Wirén; Daniel Lindmark; Marja Taussi Sjöberg; Dag Lindström; Umeå universitet; []
    Nyckelord :HUMANIORA; HUMANITIES; Historia; Tidigmodern svensk historia; History; Historia;

    Sammanfattning : The present dissertation examines various aspects of church organization in Sweden during the 17th and 18th centuries. In Sweden, as in many other European countries, the Christian religion and the organization of the Church comprised the dominant ideological power structure. LÄS MER