Sökning: "Replication fork"

Visar resultat 1 - 5 av 23 avhandlingar innehållade orden Replication fork.

  1. 1. Replication Fork Stability in Mammalian Cells

    Författare :Ingegerd Elvers; Thomas Helleday; Jan H. J. Hoeijmakers; Stockholms universitet; []
    Nyckelord :replication fork progression; replication fork stability; re-priming; DNA damage signalling; NATURAL SCIENCES; NATURVETENSKAP; molekylärgenetik; Molecular Genetics;

    Sammanfattning : Maintaining replication fork integrity is vital to preserve genomic stability and avoid cancer. Physical DNA damage and altered nucleotide or protein pools represent replication obstacles, generating replicative stress. Numerous cellular responses have evolved to ensure faithful DNA replication despite such challenges. LÄS MER

  3. 2. Maintaining DNA replication fork integrity

    Författare :Petra Groth; Stockholms universitet; []
    Nyckelord :;

    Sammanfattning : .... LÄS MER

  4. 3. Replication fork stability in mammalian cells

    Författare :Ingegerd Elvers; Stockholms universitet; []
    Nyckelord :;

    Sammanfattning : .... LÄS MER

  5. 4. Induction of apoptosis in relation to chromatin structure and inhibition of replication by DNA damage from ionizing radiation

    Författare :Jesper Torudd; Mats Harms-Ringdahl; Mats Ljungman; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ionizing radiation; DNA-loop; replication fork; Toxicology; Toxikologi;

    Sammanfattning : The theme of this thesis has been chromatin organization ranging from methodological studies to involvement in apoptotic response. The aims have been: (i) to compare the information obtained by the AVTD method and comet assay concerning DNA-loop organization, (ii) to test the hypothesis that DNA-loop relaxation could be the triggering signal for induction of apoptosis in G0-lymphocytes, and (iii) to study the dose response for inhibition of the replication fork movement and pathways for the DNA repair process at the replication fork. LÄS MER

  7. 5. Biochemical studies of mitochondrial DNA maintenance and topology

    Författare :Direnis Erdinc; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mtDNA maintenance; topoisomerase; replication;

    Sammanfattning : Mitochondria are crucial organelles in eukaryotic cells that produce the majority of adenosine trisphosphate used by cells as an energy currency to drive metabolic processes. Due to the endosymbiotic origin of mitochondria, they have their own genetic material, a small circular double-stranded molecule (mtDNA) of 16. LÄS MER