Sökning: "Renal cell carcinoma"

Visar resultat 16 - 20 av 57 avhandlingar innehållade orden Renal cell carcinoma.

  1. 16. Molecular genetic aspects of renal cell carcinoma development

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Oncology-Pathology

    Författare :Andrei Alimov; Karolinska Institutet.; Karolinska Institutet.; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kidney tumor; RCC; LOH; CGH; SKY; PTEN; chromosome 3p; chromosome 10q; chromosome 14q;

    Sammanfattning : Renal cell carcinoma (RCC) is the most common tumor of the renal parenchyma. The aim of this study was to further characterize known as well as new genetic abnormalities in a clinical material of RCC, as well as in established cell lines to gain more information about etiological and progression factors. LÄS MER

  2. 17. HIF-dependent Signaling Pathways in Cancer

    Detta är en avhandling från Lund University, Faculty of Medicine

    Författare :Elinn Johansson; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2017]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Hypoxia; ccRCC; glioma; CD44; Notch1; reactive astrocytes;

    Sammanfattning : The cellular response to hypoxia, primarily orchestrated by hypoxia-inducible factors (HIFs; mainly HIF-1α and HIF-2α), is at the center of several signaling pathways conferring aggressive tumor behavior. HIFs may be crucially involved in tumor initiation, as seen in clear cell renal cell carcinoma, as well as maintenance of resistance cancer stem cell phenotypes, as observed in glioma. LÄS MER

  3. 18. Expression and prognostic value of LRIG1 and the EGF-receptor family in renal cell and prostate cancer

    Detta är en avhandling från Umeå : Umeå university

    Författare :Marcus Thomasson; Umeå universitet.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; Renal cell carcinoma; EGFR; ErbB1-4; LRIG1; MEDICINE Surgery Oncology; MEDICIN Kirurgi Onkologi; onkologi; Oncology;

    Sammanfattning : The epidermal growth factor receptor (EGFR) family consists of four (EGFR, ErbB2, Erbb3, and ErbB4) receptor tyrosine kinases (RTK) whose signalling is important for physiological and malignant cellular functions such as proliferation, survival, migration, and differentiation. EGFR and ErbB2 in particular are established oncogenes in many solid tumours and are targets for anti-cancer treatment. LÄS MER

  4. 19. Significance of Wilms’ tumor gene 1 as a biomarker in acute leukemia and solid tumors

    Detta är en avhandling från Umeå : Umeå University

    Författare :Charlotta Andersson; Umeå universitet.; [2016]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Wilms’ tumor gene 1; biomarker; leukemia; renal cell carcinoma; ovarian carcinoma; Clinical Chemistry; klinisk kemi; patologi; Pathology;

    Sammanfattning : Wilms’ tumor gene 1 (WT1) is a zinc finger transcriptional regulator with crucial functions in embryonic development. Originally WT1 was described as a tumor suppressor gene, but later studies have shown oncogenic properties of WT1 in a variety of tumors. Because of its dual functions in tumorigenesis, WT1 has been described as a chameleon gene. LÄS MER

  5. 20. On the role of nitric oxide in bladder cancer and renal cell carcinoma

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Surgical Science

    Författare :Olof T. Jansson; Karolinska Institutet.; Karolinska Institutet.; [1999]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; urogenital tract; renal cell; transitional cell; carcinoma; nitric oxide; nitric oxide synthase; cytokines; apoptosis; BCG; cystitis;

    Sammanfattning : The role of nitric oxide (NO) in tumour biology is unclear. There are conflicting reports in the literature whether NO will promote or inhibit tumour growth. The aim of the present thesis was to investigate the role of NO in bladder cancer and renal cell carcinoma. LÄS MER