Sökning: "Remodelling"

Visar resultat 1 - 5 av 200 avhandlingar innehållade ordet Remodelling.

  1. 1. Gene regulation by chromatin remodelling complexes : SWI/SNF complex in mRNA processing and B-WICH complex in ribosomal gene expression

    Författare :Antoni Gañez Zapater; Ann-Kristin Östlund-Farrants; Christopher W.J. Smith; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chromatin remodelling; SWI SNF; Brg1; Brm; alternative splicing; cleavage and polyadenylation; B-WICH; WSTF; ribosomal genes; Cell Biology; cellbiologi;

    Sammanfattning : The aim of this project is to investigate the roles of chromatin remodelling complexes in gene regulation. It is focused on two groups of chromatin complexes: the mammalian BRG1 and BRM SWI/SNF complexes and the ISWI-containing B-WICH complex.Study 1 investigates the role of SWI/SNF complexes in alternative splicing. LÄS MER

  3. 2. RNA Polymerase I regulation by chromatin remodelling

    Författare :Yuan Guo; Ann-Kristin Östlund Farrants; Marikki Laiho; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; RNA Pol I; ribosome genes; chromatin remodelling; WSTF; CHD4; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Cell proliferation and growth is correlated with effective protein synthesis and ribosome biogenesis. The transcription of the 47S pre-ribosomal RNA by RNA Polymerase I (RNA Pol I) machinery is the rate-limiting step of ribosome biogenesis and can accounts for more than 50% of total cellular transcription. LÄS MER

  4. 3. Chromatin remodelling of ribosomal genes - be bewitched by B-WICH

    Författare :Anna Vintermist; Ann-Kristin Östlund Farrants; Ross D. Hannan; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; chromatin remodelling; ribosomal genes; rDNA; transcription; RNA polymerase I transcription; RNA polymerase III transcription; Cell Biology; cellbiologi;

    Sammanfattning : Transcription of the ribosomal genes accounts for the majority of transcription in the cell due to the constant high demand for ribosomes. The number of proteins synthesized correlates with an effective ribosomal biogenesis, which is regulated by cell growth and proliferation. LÄS MER

  5. 4. Chromatin remodelling and gene regulation

    Författare :Birgitta Gelius; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chromatin plays an important role in gene regulation, as it forms an obstacle for a number of proteins that need access to the DNA. Several protein complexes that open up the chromatin structure have been identified and some of these are important for gene regulation. LÄS MER

  7. 5. TNF-α and neurotrophins in Achilles tendinosis

    Författare :Johan Bagge; Sture Forsgren; Tomas Movin; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Achilles tendon; tendinosis; tendinopathy; neurotrophins; TNF-alpha; physical acitivity; apoptosis; proliferation; pain; remodelling; anatomi; Human Anatomy;

    Sammanfattning : Tenocytes are the principal cells of the human Achilles tendon. In tendinosis, changes in the metabolism and morphology of these cells occur. Neurotrophins are growth factors essential for the development of the nervous system. LÄS MER