Sökning: "Release factors"

Visar resultat 21 - 25 av 518 avhandlingar innehållade orden Release factors.

  1. 21. Preparation of Tablets from Reservoir Pellets with an Emphasis on the Compression Behaviour and Drug Release

    Författare :Åsa Tunón; Göran Alderborn; Michael E. Aulton; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; multiple unit tablets; extrusion-spheronisation; barrier-coating; modified drug release; pellet types; compaction; tablet properties; deformation; densification; Galenisk farmaci; Pharmaceutics; Galenisk farmaci; galenisk farmaci; Pharmaceutics;

    Sammanfattning : The preparation of multiple unit tablets was investigated in this thesis with the intention of gaining a deeper understanding of some of the factors that influence the properties of such tablets.Initially, three different types of pellets (drug, soft and disintegrant pellets) were combined as a model to investigate the ability of the mixture to form disintegrating tablets. LÄS MER

  3. 22. Microgels as Carriers for Antimicrobial Peptides : Surface-bound microgels, and factors affecting peptide interactions

    Författare :Lina Nyström; Martin Malmsten; Per Hansson; L. Andrew Lyon; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Antimicrobial peptides; Biomaterial coating; Drug delivery; Host defence peptides; Microgels; pH-responsive; Surface-bound; Pharmaceutical Physical Chemistry; Farmaceutisk fysikalisk kemi;

    Sammanfattning : With a growing number of multi-resistant bacteria against conventional antibiotics, there is an urgent need to identify new antimicrobial therapeutics. One example that has gained considerable interest is antimicrobial peptides (AMPs). LÄS MER

  4. 23. Characterization of adipose factors regulated by body weight

    Författare :Niklas Mejhert; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : White adipose tissue (WAT) constitutes our most expandable tissue and largest endocrine organ secreting hundreds of polypeptides collectively termed adipokines. Changes in WAT mass induce alterations in adipocyte secretion and function, which are linked to disturbed whole-body metabolism. LÄS MER

  5. 24. Gene therapy in epilepsy: neuropeptides and neurotrophic factors

    Författare :Irene Kanter Schlifke; Lund Wallenberg Neurocentrum; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurologi; neurophysiology; neuropsychology; Neurology; piriform cortex; hippocampus; neuropsykologi; encapsulated cells; viral vectors; GDNF; galanin; epilepsy; gene therapy; neurofysiologi;

    Sammanfattning : Temporal lobe epilepsy (TLE) is the most common form of epilepsy among adult patients, and the most problematic one as seizures cannot be controlled by currently available drugs in 30 % of patients. Gene therapy based on overexpression of endogenous anti-epileptic agents such as the neuropeptide galanin and the glial cell line-derived neurotrophic factor (GDNF) represents a promising new approach for treatment of TLE. LÄS MER

  7. 25. Factors inhibiting ingestive behavior in chronic renal failure

    Författare :Abdel-Hafiz Mamoun; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :rat; uremia; cholecystokinin octapeptide; nitric oxide; leptin; glucose; amino acids; anorexia; ingestive behavior; peritoneal dialysis solutions; hemodialysis;

    Sammanfattning : Protein-energy malnutrition and wasting occur in many patients with chronic renal failure. Reduced nutrient intake because of anorexia, nausea and vomiting, caused by uremic toxicity is an important factor. LÄS MER