Sökning: "Relapse"

Visar resultat 1 - 5 av 358 avhandlingar innehållade ordet Relapse.

  1. 1. Managing depression via the Internet : self-report measures, treatment & relapse prevention

    Författare :Fredrik Holländare; Ingemar Engström; Lil Träskman Bendz; Örebro universitet; []
    Nyckelord :Internet; depression; cognitive behaviour therapy; self-report measures; relapse prevention; MEDICINE; MEDICIN; Medicin; Medicine;

    Sammanfattning : Cognitive behaviour therapy (CBT) is an effective treatment for depression but access is limited. One way of increasing access is to offer CBT via the Internet. In Study I, guided Internet-based CBT was found to have a large effect on depressive symptoms compared to taking part in an online discussion group. LÄS MER

  2. 2. Genetic and epigenetic characterization of pediatric high hyperdiploid acute lymphoblastic leukemia

    Författare :Josef Davidsson; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; high hyperdiploid ALL; children; chromosome aberration; methylation profiling; array CGH; relapse; SNP array; clonal relationship; dup 1q ;

    Sammanfattning : The aim of this thesis was to analyze the genetic and epigenetic characteristics of pediatric high hyperdiploid acute lymphoblastic leukemia (HeH ALL), the most common type of childhood malignancy. The three original articles presented in this thesis have addressed three major questions regarding HeH ALL: what are the genetic characteristics of the most common structural abnormality – dup(1q)? Are aberrant methylation patterns involved in leukemogenesis? How do diagnostic and relapse samples relate to each other genetically? In article I we found that the proximal breakpoints of dup(1q)-positive Burkitt lymphomas (BL) and pediatric HeH ALLs cluster close to the centromere, suggesting this region to be breakprone, and that five genes on 1q were significantly overexpressed and thus potentially pathogenetically important. LÄS MER

  3. 3. DNA methylation as a prognostic marker i acute lymphoblastic leukemia

    Författare :Magnus Borssén; Sofie Degerman; Kim Vettenranta; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA methylation; acute lymphoblastic leukemia; T-ALL; Relapse; Telomere length; patologi; Pathology; Pediatrics; pediatrik;

    Sammanfattning : Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Most ALL cases originate from immature B-cells (BCP-ALL) and are characterized by reoccurring structural genetic aberrations. These aberrations hold information of the pathogenesis of ALL and are used for risk stratification in treatment. LÄS MER

  4. 4. Molecular and genetic studies in high-risk neuroblastoma

    Författare :Angela Martinez-Monleon; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; neural crest; neuroblastoma; heterogeneity; relapse; sequencing; CNVs; SVs; SNVs; LSAMP; CDK4; MDM2;

    Sammanfattning : Neuroblastoma is the most common and deadly cancer in the first year of life. Children with high-risk neuroblastoma have a very poor prognosis, despite heavy multimodal treatment, with less than 50% of 5 years of overall survival. LÄS MER

  5. 5. Hodgkin Lymphoma : Studies of Advanced Stages, Relapses and the Relation to Non-Hodgkin Lymphomas

    Författare :Rose-Marie Amini; Volker Diehl; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Hodgkin lymphoma; advanced stages; relapse; p53; EBV; Rb; cell line; Onkologi; Oncology; Onkologi; Oncology; onkologi;

    Sammanfattning : The relationship between Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) is not entirely elucidated and a clonal relation may be present more often than previously believed. Mechanisms of tumour progression and resistance to therapy are poorly understood.Between 1974 and 1994 all individuals in Sweden with both HL and NHL were identified. LÄS MER