Sökning: "Regulatory"

Visar resultat 6 - 10 av 2102 avhandlingar innehållade ordet Regulatory.

1. 6. T Regulatory Cells – Friends or Foes?

   Författare :Camilla Lindqvist; Angelica Loskog; Thomas Tötterman; Vivianne Malmström; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Treg; T regulatory cell; FoxP3; CD25; CLL; B-cell lymphoma; Clinical immunology; Klinisk immunologi; Klinisk immunologi; Clinical Immunology;

   Sammanfattning : T regulatory cells (Tregs) have been extensively studied in patients with cancer or autoimmunity. These cells hamper the immune system’s ability to clear tumor cells in cancer patients. In autoimmune diseases, on the other hand, they are not able to restrain autoreactive immune responses. LÄS MER

3. 7. Computational and experimental approaches to regulatory genetic variation

   Författare :Malin Andersen; Jacob Odeberg; John Peden; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Molecular biology; Genetics; single nucleotide polymprhism SNP ; regulatory SNP; transcription factor binding site; phylogenetic footprinting; allelic imbalance; EMSA; CD36; cardiovascular disease.; Genetic engineering including functional genomics; Genteknik inkl. funktionsgenomik;

   Sammanfattning : Genetic variation is a strong risk factor for many human diseases, including diabetes, cancer, cardiovascular disease, depression, autoimmunity and asthma. Most of the disease genes identified so far alter the amino acid sequences of encoded proteins. LÄS MER

4. 8. Cis-regulatory variation and divergence in Capsella

   Författare :Kim A. Steige; Tanja Slotte; Jeff J. Doyle; Uppsala universitet; []
   Nyckelord :Capsella; Shepherd s Purse; cis-regulatory changes; allele-specific expression; mating system shift; floral evolution; polyploidy; positive selection; purifying selection; transposable elements; small RNA; methylation; transposable element silencing; distribution of fitness effects;

   Sammanfattning : Cis-regulatory changes in e.g. promoters or enhancers that affect the expression of a linked focal gene have long been thought to be important for adaptation. In this thesis, I investigate the selective importance and genomic correlates of cis-regulatory variation and divergence in the genus Capsella, using massively parallel sequencing data. LÄS MER

5. 9. Regulatory tools for managing chemicals risk at the workplace

   Författare :Qian Ding; Sven Ove Hansson; Maria Albin; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Occupational Diseases; Chemicals; Carcinogens; Risk Management; Regulatory Toxicology; Occupational Exposure Limits; Chemicals Legislations; Risk Assessment; Acceptable Risk;

   Sammanfattning : This thesis focuses on exacerbating chemicals risk in workplaces under the background of rapid industrialization in developing countries. The overall aim is to investigate the development of regulatory tools which aim at minimizing the health risks from chemical substances in the workplace. LÄS MER

7. 10. Priority setting strategies for regulatory testing of industrial chemicals

   Författare :Anna Nordberg; Christina Rudén; Sven Ove Hansson; Nils Gunnar Lindquist; KTH; []
   Nyckelord :HUMANIORA; HUMANITIES; risk assessment; risk management; regulatory toxicology; test strategies; prioritisation; REACH; industrial chemicals; History of technology and industry; Teknik- och industrihistoria;

   Sammanfattning : For the majority of the estimated 70,000 industrial chemical substances available on the European market today there is not enough information to enable a reasonably complete assessment of the risks that they might pose to man and the environment. Any strategy for the generation of additional data for these substances should aim at making testing as efficient as possible taking into account environmental and health protection, time, monetary cost and animal welfare. LÄS MER