Sökning: "Regional cerebral blood flow"

Visar resultat 6 - 10 av 60 avhandlingar innehållade orden Regional cerebral blood flow.

  1. 6. Studies of cerebral blood flow and cerebrospinal fluid in childhood acute lymphoblastic leukemia

    Författare :Gustaf Österlundh; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :childhood acute lymphoblastic leukemia; methotrexate; neurotoxicity; cerebral blood flow; single photon emission computed tomography; cerebrospinal fluid; neuron-specific enolase; glia fibrillary acidic protein; neurofilament; ascorbyl radical;

    Sammanfattning : Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and more than 80% of the patients are cured today. Treatment might cause side effects and central nervous system (CNS) irradiation has been replaced by systemic high-dose methotrexate (MTX) and intrathecal (IT) MTX due to the risk of late effects. LÄS MER

  2. 7. Endothelium-derived substances and regional hemodynamics in experimental hypertension

    Författare :Sven-Olof Granstam; Uppsala universitet; []
    Nyckelord :Medical sciences; nitric oxide; endothelin; hypertension; rats; SHR; hemodynamics; blood pressure; blood flow; acetylcholine; carvedilol; microsphere method; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Sammanfattning : The spontaneously hypertensive rat (SHR), a model for experimental hypertension, is considered to have similarities with essential hypertension in humans. Differences between SHR and normotensive Wistar Kyoto rats (WKY) in the vascular response to endothelial-derived substances such as nitric oxide (NO) have been intensively studied in vitro. LÄS MER

  3. 8. Brain processing of experimental muscle pain and its interrelation with proprioception and muscle fatigue : positron emission tomography study

    Författare :Alexander Korotkov; Docent Tomas Graven-Nielsen; Umeå universitet; []
    Nyckelord :Experimental muscle pain; Hypertonic saline; Kinesthesia; Proprioception; Movement; Vibration; Muscle fatigue; Brain; Imaging; Positron emission tomography; Regional cerebral blood flow; Movernent; Positron emission tornography; Regional cerebral blood - flow;

    Sammanfattning : Chronic muscle pain is a significant medical and social problem and better understanding of the pathophysiological mechanisms involved is an important requirement for further development of diagnostics, treatment and rehabilitation methods. Experimental imaging studies have investigated functional neuroanatomy of different pain components. LÄS MER

  4. 9. Optimisation and Validation of Dynamic Susceptibility Contrast MRI Perfusion Measurements

    Författare :Linda Knutsson; Lund Medicinsk strålningsfysik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Nukleärmedicin; radiobiologi; Nuclear medicine; radiobiology; radiologi; tomografi; medicinsk instrumentering; tomography; medical instrumentation; Clinical physics; cerebral blood volume; mean transit time; cerebral blood flow; perfusion; dynamic susceptibility contrast MRI arterial input function; Klinisk fysiologi; radiology;

    Sammanfattning : The studies presented in this thesis concern the optimisation and evaluation of the dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) technique for the assessment of perfusion-related parameters of the brain, such as cerebral blood flow (CBF), cerebral blood volume (CBV) and mean transit time (MTT). Several methodological factors influence these measurements, for example, contrast-agent administration, arterial input function (AIF) registration, choice of deconvolution algorithm and the choice of pulse-sequence parameters. LÄS MER

  5. 10. Posture and brain function in dementia. A study with special reference to orthostatic hypotension

    Författare :Ulla Passant; Sektion IV; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; falls and fractures.; white matter disease; hypoperfusion; frontal lobes; regional cerebral blood flow; blood pressure; orthostatic hypotension; Organic dementia; normal subjects; Psychiatry; clinical psychology; psychosomatics; Psykiatri; klinisk psykologi; psykosomatik;

    Sammanfattning : Orthostatic hypotension (OH) is believed to be an important cause of cerebral hypoperfusion, leading to chronic fatigue, blurred vision, unsteadiness, dizziness and sometimes syncope. It may also result in episodes of confusion, falls and fractures. The coupling between OH and organic dementia is not clear. LÄS MER