Sökning: "Recombinant antibody microarray"
Visar resultat 1 - 5 av 14 avhandlingar innehållade orden Recombinant antibody microarray.
1. Design of recombinant antibody microarrays for global proteome analysis
Sammanfattning : Antibody-based microarrays are among the new, rapidly emerging technologies within the field of proteomics that has the potential to evolve into a key proteomic research tool, providing novel means to perform early diagnostics, identify biomarkers and gain insights into disease biology. The aim of this thesis, based on five original papers, was to develop antibody microarrays based on human recombinant scFv antibody fragments for large-scale comprehensive proteome analysis. LÄS MER
2. Protein Microarrays Based on Single Framework Recombinant Antibody Fragments (SINFABS) - Catcher and Carrier - A Crucial Combination
Sammanfattning : Antibody-based microarrays are among the novel class of rapidly evolving proteomic technologies. In recent years, antibody microarrays have emerged as a unique tool for high-throughput protein expression profiling with great promise within biomedicine and a wide range of potential applications, including disease diagnostics and biomarker discovery. LÄS MER
3. Strategies for Miniaturized Biomarker Detection
Sammanfattning : The aim of this thesis is development and application of different miniaturized strategies for detection of biomarkers. The biomarker PSA (prostate specific antigen), which is prostate cancer specific, has been the main focus of the thesis. LÄS MER
4. Design of antibody microarrays for global profiling of membrane proteins and soluble proteins
Sammanfattning : Antibody-based microarrays have emerged as an established proteomic technology allowing multiplexed and sensitive profiling of complex proteomes, in a high-throughput and miniaturized manner. Recently, numerous applicative efforts have been pursued generating disease-associated protein signatures that now could be further explored for improved disease diagnostics, prognostics and classification. LÄS MER
5. Tailoring of Antibody Arrays - Technical Advances Towards Global Proteome Analysis
Sammanfattning : Abstract The number of cancer and autoimmune disease diagnoses increases in our society, which place high demands on the health care system. Being able to tailor treatments for each individual patient is called "Personalized medicine", and could revolutionize the care in the future. LÄS MER