Sökning: "Raloxifene"

Visar resultat 1 - 5 av 12 avhandlingar innehållade ordet Raloxifene.

  1. 1. Estrogen and raloxifene in experimental arthritis and osteoporosis

    Författare :Caroline Jochems; Göteborgs universitet; []
    Nyckelord :rheumatoid arthritis; osteoporosis; estrogen; raloxifene; mice;

    Sammanfattning : ABSTRACT In postmenopausal rheumatoid arthritis (RA), both the estrogen deficiency and the inflammatory disease contribute to the development of generalized osteoporosis. This leads to an increased risk of fracture, with high morbidity and mortality. More than 50% of women with postmenopausal RA suffer from osteoporosis. LÄS MER

  3. 2. Titanium Oxide and Bone Anchorage: Role of the Complement System, and Delivery of Osteoporosis Drugs from Mesoporous TiO2

    Författare :Necati Harmankaya; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; titania; complement; photocatalysis; ovariectomy; alendronate; raloxifene;

    Sammanfattning : The clinical success of bone implants of titanium (Ti) is largely ascribed to the biological performance and the physicochemical properties of the outermost titanium(IV)dioxide (TiO2) layer. Several advancements have been done on TiO2 in order to optimize its healing and anchorage to bone, and there is a need for further understanding and control of the molecular reactions preceding long-term osseointegration. LÄS MER

  4. 3. Immune regulation by selective estrogen receptor modulators

    Författare :Angelina I Bernardi; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; Endocrinology; Mice; Lasofoxifene; Bazedoxifene; Raloxifene; Estrogen; Osteoporosis; B cells; T cells; Rheumatoid arthritis;

    Sammanfattning : At menopause, the levels of estrogen decline, leading to loss of estrogen-mediated protective effects on bone and an increased risk of osteoporosis. Hormone replacement therapy, containing estrogen, has been used for many years to prevent and treat osteoporosis in postmenopausal women. LÄS MER

  5. 4. Molecular mechanisms of estrogen and antiestrogen action

    Författare :Tomas Barkhem; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Estrogen receptor; SHBG; tamoxifen; raloxifene; pS2; p1 60 coactivator; SRC-1; TIF-2;

    Sammanfattning : Estrogen is a key regulatory hormone that affects numerous physiological processes. The estrogen receptors (ER), ER alpha and ER beta, play a central role in mediating the effects of both estrogens and antiestrogens. Estrogen signaling has proven to be multifaceted and the precise mechanism of action remains in many cases elusive. LÄS MER

  7. 5. Analysis of DNA adducts formed by tamoxifen and related antiestrogenic and estrogenic compounds in rats

    Författare :Heli Rajaniemi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :DNA adducts; 32P-postlabelling; tamoxifen; toremifene; diethylstilbestrol; clomiphene; triparanol; raloxifene; antiestrogen; estrogen; SERM; genotoxicity; cancer;

    Sammanfattning : The work presented herein has focused on DNA adduct formation by the non-steroidal antiestrogen tamoxifen and its analogues. Tamoxifen, [(Z)-1-{4-[2-(dimethylamino)-ethoxy]phenyl}-1,2-diphenyl-1-butene], is widely used in the treatment of breast cancer and its recognised side effect is endometrial cancer. LÄS MER