Sökning: "Raf-1"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet Raf-1.

1. 1. The Effects of SSRI Treatment on Human Placenta and Embryo

   Författare :Helena Kaihola; Helena Åkerud; Inger Sundström-Poromaa; Jocelien Olivier; Olav Spigset; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antenatal depression; embryo; embryo development; fluoxetine; gene expression; NGF; placenta; protein expression; Raf-1; ROCK; signaling pathways; SSRI; Medicinsk vetenskap; Medical Science; Obstetrik och gynekologi; Obstetrics and Gynaecology;

   Sammanfattning : During pregnancy, 4 - 7% of women suffer from major depressive disorder. When antidepressive treatment is needed, selective serotonin reuptake inhibitors (SSRIs) are the most commonly used. Although severe complications from SSRI treatment are rare, association with a number of adverse pregnancy and fetal outcomes has been found. LÄS MER

3. 2. Ribosome display for selection and evolution of affibody molecules

   Författare :Sebastian Grimm; Per-Åke Nygren; Mike Taussig; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; affibody; ribosome display; phage display; combinatorial protein engineering; library; murine IgG1; SATB1; Ras; Raf; Genetic engineering including functional genomics; Genteknik inkl. funktionsgenomik; SRA - Molecular Bioscience; SRA - Molekylär biovetenskap;

   Sammanfattning : Affinity proteins are invaluable tools in biotechnological and medical applications. This thesis is about combinatorial protein engineering principles for the generation of novel affinity proteins to purify mouse immunoglobulin, detect a potential cancer marker protein or inhibit a cell proliferation pathway. LÄS MER

4. 3. Affinity protein based inhibition of cancer related signaling pathways

   Författare :Erik Vernet; Torbjörn Gräslund; Antonino Cattaneo; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Affibody; cancer; endoplasmic reticulum retention; EGFR; HER2; IGF-1R; Raf; Ras; Bioengineering; Bioteknik;

   Sammanfattning : Dysregulation of protein activity, caused by alterations in protein sequence, expression, or localization, is associated with numerous diseases. In order to control the activity of harmful protein entities, affinity ligands such as proteins, oligonucleotides or small molecules can be engineered to specifically interact with them to modulate their function. LÄS MER

5. 4. Studies of induced transcription in response to an activated Ha-ras, TPA and UV radiation in keratinocytes

   Författare :Mats Nilsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :keratinocytes; Ha-ras; ultraviolet radiation; transcription factor; TPA; NF-kB;

   Sammanfattning : The mutational activation of the Ha-ras gene in keratinocytes has been shown to occur during the initiation step in the mouse skin model for multistage carcinogenesis. Skin tumor promoters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) and ultraviolet radiation (UVR) stimulate a selective outgrowth of initiated keratinocytes to form benign tumours (papillomas). LÄS MER

7. 5. Fibroblast growth factor-induced signal transduction

   Författare :Peter Klint; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Biokemi; Biochemistry; Biokemi; molekylär cellbiologi; Molecular Cellbiology;

   Sammanfattning : Fibroblast growth factors (FGFs) evoke cellular responses by binding to FGF receptors (FGFRs). FGFRs are cell surface expressed membrane-spanning receptors with intrinsic stimulatable tyrosine kinase activity. This thesis describes the cell proliferation or differentiation. LÄS MER