Sökning: "Radionuclide therapy"

Visar resultat 6 - 10 av 74 avhandlingar innehållade orden Radionuclide therapy.

1. 6. Tumour Targeting Using Radiolabelled EGF Conjugates : Preclinical Studies

   Författare :Åsa Liljegren Sundberg; Jörgen Carlsson; Lars Gedda; Vladimir Tolmachev; Erik Blomquist; Gregory P. Adams; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radiation sciences; targeting; tumour; EGF; radionuclide; gefitinib; Iressa; ZD1839; glioma; therapy; diagnostics; Strålningsvetenskap; Radiation biology; Strålningsbiologi;

   Sammanfattning : Tumour targeted radiotherapy is an appealing approach for treatment of disseminated tumour cells. A targeting agent that specifically binds to a structure on tumour cells is then used to transport therapeutically relevant radionuclides. The epidermal growth factor receptor, EGFR, is overexpressed on tumour cells in several malignancies, e.g. LÄS MER

3. 7. Methods for image-based dosimetry and radiobiological modelling in radionuclide therapy

   Författare :Johan Gustafsson; Lund Medicinsk strålningsfysik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; radionuclide therapy; dosimetry; biologically effective dose; 177Lu-DOTATATE;

   Sammanfattning : In radionuclide therapy (RNT), radioactive pharmaceuticals are administered for therapeutic purposes. Dosimetry, i.e. the estimation of the absorbed dose to various targets, can potentially lead to a better understanding of the therapeutic effects in RNT and allow for individualization of the therapy. LÄS MER

4. 8. The ADAPT scaffold as a tool for diagnostic imaging and targeted therapy

   Författare :Emma von Witting; Sophia Hober; Inger Sandlie; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Protein G; ABD; ADAPT; affinity proteins; antibody; protein engineering; targeted therapy; nuclear medicine; molecular imaging; HER2; radionuclide therapy; Bioteknologi; Biotechnology;

   Sammanfattning : Molecular recognition, or the specific interactions between a protein and its ligand, is central to biology and a key factor for many different clinical and technical applications. Despite antibodies being only one of many different affinity proteins, it has by far been the most successful. LÄS MER

5. 9. Development of Affibody molecules for radionuclide molecular imaging and therapy of cancer

   Författare :Hadis Honarvar; Vladimir Tolmachev; Raymond M. Reilly; Uppsala universitet; []
   Nyckelord :Affibody molecules; HER2; Molecular imaging; Radionuclide targeted therapy; Radionuclide molecular imaging; Labeling chemistry; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

   Sammanfattning : Affibody molecules are a promising class of scaffold-based targeting proteins for radionuclide-based imaging and therapy of cancer. This thesis work is based on 5 original research articles (papers I-V), which focus on optimization of molecular design of HER2-binding Affibody variants for high contrast imaging of this predictive biomarker as well as development of Affibody molecules suitable for radionuclide-based targeted therapies. LÄS MER

7. 10. Peptide Receptor Radionuclide Therapy in Neuroendocrine Neoplasms : Aspects of tumour characteristics, receptor recycling and peptide mass

   Författare :Ulrika Jahn; Anders Sundin; Mark Lubberink; Ulrike Garske-Román; Mona-Elisabeth Rootwelt-Revheim; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroendocrine tumors; Peptide receptor radionuclide therapy PRRT ; Peptide; Small-Intestinal; Pancreatic; Dosimetry; Somatostatin receptor;

   Sammanfattning : Neuroendocrine neoplasm (NEN) can arise in any part of the body, but most commonly in the lungs, bronchi, and the gastrointestinal tract including the pancreas. They combine neuroendocrine and tissue-of-origin-specific characteristics; explaining different symptoms depending on the organ of origin. LÄS MER