Sökning: "Radionuclide therapy"

Visar resultat 21 - 25 av 74 avhandlingar innehållade orden Radionuclide therapy.

  1. 21. Realistic tissue dosimetry models using Monte Carlo simulations. Applications for radionuclide therapies

    Författare :Erik Larsson; Lund Medicinsk strålningsfysik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; internal dosimetry; radionuclide therapy; Monte Carlo; small scale dosimetry;

    Sammanfattning : Radionuclide therapy (RNT) is a generic term for treatment modalities that use a radionuclide labeled to a target-specific molecule. This so-called radiopharmaceutical accumulates in the target, where the ionizing radiation damages the cells. At sufficient levels of radiation, the cells cannot repair themselves. LÄS MER

  3. 22. Affibody-mediated targeting of HER-family receptors for cancer imaging and therapy

    Författare :Charles Dahlsson Leitao; Stefan Ståhl; John Löfblom; Christoph Rader; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer therapy; radionuclide imaging; affibody molecules; HER-receptors; prodrug; protein design; Cancerterapi; radionuklidavbildning; affibody molekyler; HER-receptorer; prodrog; proteindesign; Bioteknologi; Biotechnology;

    Sammanfattning : Proteins are remarkable molecules with diverse and specialized functions playing essential roles in most biological processes. One such function is protecting us from diseases by the action of antibodies in our immune system that can recognize and mediate the destruction of invading pathogens by binding to foreign epitopes found on non-self proteins. LÄS MER

  4. 23. Biomarker discovery and assessment for prediction of kidney response after 177Lu-octreotate therapy

    Författare :Emil Schüler; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PRRT; somatostatin; radionuclide therapy; 177Lu-octreotate; scintigraphy; renal function; toxicity; kidney response; radiation biology; microarray; molecular biomarkers; ionizing radiation; miRNA; proteomics; transcriptional response;

    Sammanfattning : Patients suffering from neuroendocrine tumors are oftentimes presented with spread disease at the time of diagnosis. Therapy using somatostatin analogs is today the only potentially curative treatment option for these patients. LÄS MER

  5. 24. Antibody Mediated Radionuclide Targeting of HER-2 for Cancer Diagnostics and Therapy : Preclinical Studies

    Författare :Mikael Persson; Per-Uno Malmström; Vladimir Tolmachev; Jörgen Carlsson; Marion De Jong; Uppsala universitet; []
    Nyckelord :Molecular medicine; Neoplasm Antibodies; Targeted Radiotherapy; Radionuclide Imaging; Molekylärmedicin;

    Sammanfattning : Targeted radionuclide therapy (TRT) holds great promise for the treatment of cancer. In TRT, radioactive nuclides are delivered specifically to tumours by molecules that recognise and bind to structures overexpressed by, or specific to, cancer cells. LÄS MER

  7. 25. Therapy of neuroendocrine tumors with 177Lu-octreotate - Human tumor cell types and models and optimization of treatment : Terapi av neuroendokrina tumörer med 177Lu-octreotate

    Författare :Johanna Dalmo; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; somatostatin; radionuclide therapy; receptor up-regulation; RBP; nephrotoxicity;

    Sammanfattning : Neuroendocrine (NE) tumors (NET) have often metastasized at the time of diagnose, which makes it hard to cure patients with NET. Radiolabeled hormone analogues (especially somatostatin analogues, SS) can be used for diagnostics (e.g. 111In-octreotide) and therapy (e. LÄS MER