Sökning: "Radioimmunotherapy"

Visar resultat 16 - 20 av 27 avhandlingar innehållade ordet Radioimmunotherapy.

1. 16. Diagnosis and Radioimmunotherapy of Head and Neck Squamous Cell Carcinomas

   Författare :Tomas Ekberg; Matti Anniko; Jörgen Carlsson; Eva Munck-Wikland; Uppsala universitet; []
   Nyckelord :Otorhinolaryngology; head and neck squamous cell carcinoma; tumor targeting; radionuclide targeting; PET; therapy; diagnistics; antibodies; Otorhinolaryngologi;

   Sammanfattning : The diagnosis and treatment of patients with advanced tumors in the head and neck is an interesting challenge where there is a need for new approaches in diagnostics and adjuvant treatment. Differences in antigen expression between tumors and normal tissues provide a means for application of antibody-based targeting techniques. LÄS MER

3. 17. Radioimmunotherapy in an Immunocompetent Tumor Model utilizing a 177Lu-mAb

   Författare :Erika Elgström; Tumörmikromiljö; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Radioimmunotherapy (RIT) is a therapeutic strategy in which radionuclides are conjugated to monoclonal antibodies that bind to tumor-associated antigens in the tumor, so that the decay of the radionuclide takes place inside the tumor. The aim of the research presented in this thesis was to investigate the effects of RIT (utilizing the radioconjugated antibody 177Lu-BR96) on an inoculated tumor and the development of metastases. LÄS MER

4. 18. High-Dose Radioimmunotherapy and Extracorporeal Depletion in A Syngeneic Rat Tumor Model

   Författare :Linda Mårtensson; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : ABSTRACT Radioimmunotherapy (RIT) consists of using monoclonal antibodies (mAbs) recognizing tumor-selective antigens, as carriers of cytotoxic radionuclides to tumor tissue. RIT has been effective in lymphoma but less successful in solid tumors. LÄS MER

5. 19. RADIOIMMUNOTHERAPY & EXTRACORPOREAL ADSORPTION Preclinical Studies of the Pharmacokinetics & Biotinylation of Radioimmunoconjugates in Immunocompetent Rats

   Författare :Zhongmin Wang; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; onkologi; cancer; oncology; cancerology; Cytologi; Cytology; extracorporeal adsorption; tri-functional chelator; maximal tolerable dose; biotin; intraperitoneal administration; biodistribution; pharmacokinetics; biotinylation; radiolabeling; rat; monoclonal antibody; radionuclide;

   Sammanfattning : Extracorporeal adsorption (ECAT) is a novel strategy to reduce activity in whole body (WB), blood and radiosensitive organs by removing the excess of radiolabeled and biotinylated monoclonal antibody (MAb) from blood so that tumor/normal tissue ratio (T/N) could be improved. By increasing T/N, higher amounts of radiolabeled MAb might be administered, making it possible to treat disseminated carcinomas. LÄS MER

7. 20. Synthesis of functional derivatives of [B12H12]2- anion for boron neutron capture therapy, radiodiagnostics and radioimmunotherapy

   Författare :Igor Sivaev; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemistry; Kemi; Chemistry; Kemi; organisk kemi; Organic Chemistry;

   Sammanfattning : Functional derivatives of dodecahydro-closo-dodecaborate anion [B12H12]2- are potential candidates for medical application in boron neutron capture therapy for cancer and as linkers for the introduction of radiohalogen label into biomolecules for radioimmunodiagnostics and radioimmunotherapy.In this study, new approaches for the synthesis of functional derivatives of the closo-dodecaborate anion were developed and a series of novel functional derivatives were prepared. LÄS MER