Sökning: "Radiation Therapy Optimization"

Visar resultat 1 - 5 av 37 avhandlingar innehållade orden Radiation Therapy Optimization.

  1. 1. Toward Robust Optimization of Adaptive Radiation Therapy

    Författare :Michelle Böck; Anders Forsgren; Minsun Kim; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; optimization; adaptive radiation therapy; radiation therapy treatment planning; uncertainty; robust optimization; stochastic programming; Tillämpad matematik och beräkningsmatematik; Applied and Computational Mathematics;

    Sammanfattning : Adaptive radiation therapy is an evolving cancer treatment approach which relies on adapting the treatment plan in response to patient-specific interfractional geometric variations occurring during the fractionated treatment. If those variations are not addressed through adaptive replanning, the resulting treatment quality may be compromised. LÄS MER

  3. 2. Multicriteria optimization for managing tradeoffs in radiation therapy treatment planning

    Författare :Rasmus Bokrantz; Anders Forsgren; Karl-Heinz Küfer; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Optimization; multicriteria optimization; robust optimization; Pareto optimality; Pareto surface approximation; Pareto surface navigation; intensity-modulated radiation therapy; volumetric-modulated arc therapy; intensity-modulated proton therapy; Optimering; flermålsoptimering; robust optimering; Paretooptimalitet; Paretofrontsapproximation; Paretofrontsnavigering; intensitetsmodulerad strålterapi; rotationsterapi; intensitetsmodulerad protonterapi;

    Sammanfattning : Treatment planning for radiation therapy inherently involves tradeoffs, such as between tumor control and normal tissue sparing, between time-efficiency and dose quality, and between nominal plan quality and robustness. The purpose of this thesis is to develop methods that can facilitate decision making related to such tradeoffs. LÄS MER

  4. 3. Robust optimization of radiation therapy accounting for geometric uncertainty

    Författare :Albin Fredriksson; Anders Forsgren; Timothy C. Y. Chan; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Optimization; intensity-modulated proton therapy; uncertainty; robust planning; setup error; range error; intensity-modulated radiation therapy; multicriteria optimization;

    Sammanfattning : Geometric errors may compromise the quality of radiation therapy treatments. Optimization methods that account for errors can reduce their effects.The first paper of this thesis introduces minimax optimization to account for systematic range and setup errors in intensity-modulated proton therapy. LÄS MER

  5. 4. Automated radiation therapy treatment planning by increased accuracy of optimization tools

    Författare :Lovisa Engberg; Anders Forsgren; Marina A. Epelman; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Optimization; intensity-modulated radiation therapy; radiation therapy treatment planning; automated radiation therapy treatment planning; interior-point methods; Optimering; intensitetsmodulerad strålbehandling; dosplanering; automatiserad dosplanering; inrepunktsmetoder; Mathematics; Matematik;

    Sammanfattning : Every radiation therapy treatment is preceded by a treatment planning phase. In this phase, a treatment plan that specifies exactly how to irradiate the patient is designed by the treatment planner. LÄS MER

  7. 5. Utilizing Problem Structure in Optimization of Radiation Therapy

    Författare :Fredrik Carlsson; Anders Forsgren; Edwin Romeijn; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Optimization; intensity-modulated radiation therapy; conjugate-gradient method; step-and-shoot delivery; column generation; quasi-Newton method; regularization; sequential quadratic programming; Optimization; systems theory; Optimeringslära; systemteori;

    Sammanfattning : In this thesis, optimization approaches for intensity-modulated radiation therapy are developed and evaluated with focus on numerical efficiency and treatment delivery aspects. The first two papers deal with strategies for solving fluence map optimization problems efficiently while avoiding solutions with jagged fluence profiles. LÄS MER