Sökning: "RU 486"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden RU 486.

  1. 1. Regulation of apoptosis and steroidogenesis in ovarian preovulatory granulosa cells

    Författare :Eva Svensson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; apoptosis; granulosa cells; luteinizing hormone; progesterone receptor; RU 486; Org 31710; leptin; steroidogenesis;

    Sammanfattning : Only a minute fraction of ovarian follicles present in a foetal ovary will complete the path to ovulation. The majority of the follicles will instead undergo atresia, a hormonally controlled apoptotic process. Apoptosis occurs throughout follicle development, with an extensive reduction in the number of follicles present at birth. LÄS MER

  3. 2. Expression and regulation of vasoactive substances, sex steroids and their receptors in placenta during normal pregnancy and preeclampsia

    Författare :Josefine Nasiell; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Despite intense studies preeclampsia remains enigmatic and a major cause of maternal and fetal morbidity and mortality. It is now widely accepted that the placenta has a central role in preeclampsia; delivery of the placenta is the only known cure. LÄS MER

  4. 3. Endogenous and exogenous glucocorticoid effects in a model of allergic airway inflammation

    Författare :Susanna Kumlien Georén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Airway; allergy; asthma; eosinophil; glucocorticoids; hypothalamus-pituitary-adrenal HPA axis; inflammation; nerve growth factor NGF ; neuroimmunology; psychoneuroimmunology; restraint; stress;

    Sammanfattning : Allergic asthma and rhinitis are inflammatory diseases of the airways. Allergic asthma is characterized by eosinophilic inflammation, reversible bronchoconstriction and airway hyperresponsiveness, whereas patients with rhinitis suffer from nasal inflammation, leading to rhinorrhea and nasal congestion. LÄS MER

  5. 4. Progesterone receptor-mediated effects on apoptosis in periovulatory granulosa cells

    Författare :Emilia Rung; Göteborgs universitet; []
    Nyckelord :;

    Sammanfattning : The most common fate of developing ovarian follicles is demise due to a process known as atresia. Regulation of atresia is dependent on the developmental stage of the follicles, resulting in a continuous reduction of the number of follicles as they differentiate and grow towards ovulation. LÄS MER

  7. 5. In vitro Studies of β-cell Death and Survival. Modulation by Adenoviral Vectors and Bcl-2 Overexpression

    Författare :Andreea Roxana Barbu; Nils Welsh; Decio Eiziric; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; β-cell; cytokine; mitochondrial membrane potential; Bcl-2; Adenoviral vector; Adenovirus; IFN-α; Diabetes; Cellbiologi; Cell biology; Cellbiologi;

    Sammanfattning : Type 1 diabetes is a multifactorial disease resulting from the selective destruction of insulin-producing β-cells within the pancreatic islets of Langerhans. The mechanisms of β-cell death are not fully understood but cytokines are important mediators of this process. LÄS MER