Sökning: "ROESY"

Hittade 5 avhandlingar innehållade ordet ROESY.

1. 1. NMR studies of host-pathogen interactions

   Författare :Katja Petzold; Jürgen Schleucher; Torleif Härd; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NMR; regulatory RNA; HBV; H.pylori; phospholipids; ROESY; Molecular biophysics; Molekylär biofysik; biokemi; Biochemistry;

   Sammanfattning : This thesis describes the use of Nuclear Magnetic Resonance (NMR) for characterizing two host-pathogen interactions: The behavior of a regulatory RNA of the Hepatitis B virus (HBV) and the attachment of Helicobacter pylori (H. pylori) to the gastric mucosa. LÄS MER

3. 2. Structure-Based Design and Synthesis of Protease Inhibitors Using Cycloalkenes as Proline Bioisosteres and Combinatorial Syntheses of a Targeted Library

   Författare :Fredrik Thorstensson; Ingemar Kvarnström; Charles Hedgecock; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; organic chemistry; organic synthesis; combinatorial synthesis; metathesis; olefin metathesis; thrombin; HCV; NS3; protease; proline isosteres; inhibitor; Organic synthesis; Organisk syntes;

   Sammanfattning : Structure-based drug design and combinatorial chemistry play important roles in the search for new drugs, and both these elements of medicinal chemistry were included in the present studies. This thesis outlines the synthesis of protease inhibitors against thrombin and the HCV NS3 protease, as well as the synthesis of a combinatorial library using solid phase chemistry. LÄS MER

4. 3. Terpenoid Plant Metabolites - Structural Characterization and Biological Importance

   Författare :Eliana Maldonado; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Terpenoid Sesquiterpene lactones Breast-cancer cell lines Cytotoxicity Antileishmanicial Structural characterization;

   Sammanfattning : In response to the challenges of their local environments, organisms produce of a large number of chemical diverse compounds with complex stereochemistry and reactive functional groups. These characteristics enable them to interact and bind specifically to biological target molecules and exert various biological activities, and have assured that Natural products continues to be an important source of bioactive compounds, which, for example, facilitate the search for new lead structures that can be developed into new pharmaceuticals. LÄS MER

5. 4. Development of new NMR techniques and the structure of the N-terminal domain of Escherichia coli DnaB helicas

   Författare :Johan Weigelt; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :NMR spectroscopy; DnaB; helicase;

   Sammanfattning : New techniques applicable in biomolecular nuclear magnetic resonance (NMR) spectroscopy were developed. The three-dimensional structure of the N-terminal domain of Escherichia coli DnaB helicase was determined at atomic resolution using heteronuclear multidimensional NMR techniques. LÄS MER

7. 5. Glutaredoxin 3 from Escherichia coli : NMR structure analysis and structural aspects of the enzymatic mechanism

   Författare :Kerstin Nordstrand; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The structure of Escherichia coli glutaredoxin 3 (Grx3) was investigated using NMR spectroscopy in combination with isotope labeling. Nearly complete sequence specific assignment were obtained for the reduced Grx3 using a 15N enriched protein sample. LÄS MER