Sökning: "RNase R"
Hittade 5 avhandlingar innehållade orden RNase R.
1. EF-Tu and RNase E : Essential and Functionally Connected Proteins
Sammanfattning : The rate and accuracy of protein production is the main determinant of bacterial growth. Elongation Factor Tu (EF-Tu) provides the ribosome with aminoacylated tRNAs, and is central for its activity. In Salmonella enterica serovar Typhimurium, EF-Tu is encoded by the genes tufA and tufB. LÄS MER
2. Post-transcriptional regulation by RNases in Streptococcus pyogenes
Sammanfattning : Ribonucleases (RNases) are proteins that adjust cellular RNA levels by processing RNA transcripts, leading to their stabilization or degradation. RNases are grouped based on their ability to cleave the transcript internally (endoRNases) or degrade the transcript starting from the ends (exoRNases). LÄS MER
3. Conformationally Constrained Oligonucleotides for RNA Targeting
Sammanfattning : A short oligonucleotide sequence as in a single-stranded antisense oligo nucleotides (AON) or in double-stranded small interfering RNAs (siRNA) can modulate the gene expression by targeting against the cellular mRNA, which can be potentially exploited for therapeutic purposes in the treatment of different diseases. In order to improve the efficacy of oligonucleotide-based drugs, the problem of target affinity, nuclease stability and delivery needs to be addressed. LÄS MER
4. Novel Pentofuranose Chemistry to Modulate RNA Function
Sammanfattning : Chemical modifications of oligonucleotides provide an important tool to understand how the natural substrate works as well as how to improve their biochemical and biological properties as potential therapeutics and diagnostics. Our carba-LNA (2',4'-carba-bridged Locked Nucleic Acid) modified oligo-DNA or -RNA have been found to be useful to modulate oligo-RNA and -DNA activity. LÄS MER
5. Genes that modulate or mediate dopaminergic neurotransmission : expression of the human prodynorphin gene and association studies with candidate genes in an alcohol patient sample
Sammanfattning : The development of alcoholism may at least partly be attributed to the effect of ethanol on reward and reinforcement. As a genetic influence in the vulnerability to alcoholism and drug abuse has been documented, it is of interest to investigate genes active in brain structures which mediate reward and reinforcement. LÄS MER