Sökning: "RNase III"

Visar resultat 16 - 20 av 22 avhandlingar innehållade orden RNase III.

  1. 16. HHV-8/KSHV association with tumor cells during development of Kaposi sarcoma

    Författare :Fatemeh Pak; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Kaposi's sarcoma (KS) is a highly and abnormally vascularized tumor-like lesion which usually presents as a cutaneous disease and progresses to extracutaneous, systemic spread usually in the gastrointestinal (GI) tract, lungs, oral cavity and lymph nodes. It is the most common neoplasm of AIDS patient and included in the staging of HIV disease progression. LÄS MER

  3. 17. Genotoxic stress : novel biomarkers and detection methods : uncovering RNAs role in epigenetics of carcinogenesis

    Författare :Edyta Zofia Bajak; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Cancer is a complex disease that is caused by the interplay of multiple genes and diverse environmental factors. As such, there has been continual debate as to which component of this complicated process towards development of neoplasia plays the most important role. LÄS MER

  4. 18. Mechanistic characterization of post-transcriptional gene silencing

    Författare :Cecilia Dahlgren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : With the ongoing task of identifying and characterizing genes in the human genome, there is a great demand for tools to study these genes. Today, reverse genetics is the most effective way to explore gene function. This involves suppression of the gene of interest by a set of manipulation techniques. LÄS MER

  5. 19. Keratinocyte differentiation. Involvement of the growth hormon (GH)/insulinlike growth factor1 (IGFI) axis and IGF1 post receptor signaling

    Författare :Elisabeth Björntorp Mark; Göteborgs universitet; []
    Nyckelord :IGF1R; GH; Id1; keratinocytes; psoriasis;

    Sammanfattning : At cellular level, little is known about the genes that regulate keratinocyte differentiation andproliferation. Psoriasis is regarded as a T-cell mediated inflammatory disease with hyperproliferativekeratinocytes. LÄS MER

  7. 20. The RNA exosome and the maintenance of genome integrity

    Författare :Judit Domingo Prim; Neus Visa; Andrés Aguilera; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; EXOSC10; RRP6; DNA damage; diRNA; DDRNA; DNA end resection; homologous recombination; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : The RNA exosome is a ribonucleolytic complex that acts on different RNA substrates and plays important roles in RNA metabolism. In recent years, the synthesis and the processing of RNA have been directly linked to the integrity of the genome. LÄS MER