Sökning: "RNase III"

Visar resultat 11 - 15 av 22 avhandlingar innehållade orden RNase III.

  1. 11. Transcriptional regulation of the Epstein-Barr virus nuclear antigen 1 gene in latent and lytic stages of infection

    Författare :Henrik Zetterberg; Göteborgs universitet; []
    Nyckelord :Epstein-Barr virus; EBNA1; Burkitt s lymphoma; nasopharyngeal carcinoma; ; B-lymphocyte; transformation; transcriptional regulation;

    Sammanfattning : Epstein-Barr virus (EBV) is a lymphotropic herpesvirus that infects more than 90% of humans worldwide. The virus is the causative agent of infectious mononucleosis, a self-limiting lymphoproliferative disorder, and is also associated with a variety of malignancies including Burkitt's lymphoma (BL), Hodgkin's disease (HD), nasopharyngeal carcinoma (NPC), and lymphoproliferative disorders in immunocompromised individuals. LÄS MER

  3. 12. Studies on mRNA turnover in bacteria

    Författare :Martin Persson; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Microbiology; aprE; GlpP; glpD; mRNA secondary structure; Bacillus subtilis; mRNA stability; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

    Sammanfattning : Genetic information, which is stored in DNA, is transferred to messenger RNA (mRNA) in a process called transcription. mRNAs are then translated by ribosomes into proteins which, with some important exceptions, catalyze chemical reactions in cells. Since cells must be able to adapt to changes in the environment, mRNAs must be unstable. LÄS MER

  4. 13. Novel inhibitors of Chlamydia trachomatis virulence

    Författare :Carlos Nunez-Otero; Åsa Gylfe; Sven Bergström; Fredrik Almqvist; Jörgen Johansson; Patrik Bavoil; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chlamydia trachomatis; 2-pyridone; small molecules; KSK213; Structure-Activity Relationships SAR ; antibiotic resistance; target identification; transcription; RNA; progeny; infectivity;

    Sammanfattning : Chlamydia trachomatis is an obligate intracellular bacterium that infects over 100 million people globally every year. Chlamydia infections can be persistent, cause infertility and blindness, adding an economical burden in the healthcare systems. LÄS MER

  5. 14. A small amoeba at the crossroads of the big RNAi world : MicroRNA biogenesis and Argonaute function in Dictyostelium discoideum

    Författare :Zhen Liao; Fredrik Söderbom; Gerhart E. H. Wagner; Christina Dixelius; Kriton Kalantidis; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; RNAi; microRNA; Argonaute protein; miRNA biogenesis; Dictyostelium discoideum; social amoeba; Dicer; development; growth; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Sammanfattning : Small non-coding RNA (ncRNA) mediated gene silencing, known as RNAi, is a key regulatory mechanism of gene expression in eukaryotes. MicroRNAs (miRNA), one major type of small ncRNAs, are about 21nt long and bound by Argonaute proteins. LÄS MER

  7. 15. Novel Pentofuranose Chemistry to Modulate RNA Function

    Författare :Mansoureh Karimiahmadabadi; Jyoti Chattapadhyaya; Jesper Wengel; Uppsala universitet; []
    Nyckelord :pentofuranose chemistry; conformationally locked nucleoside; carbocyclic-LNA; bicyclo[2.2.1]heptane;

    Sammanfattning : Chemical modifications of oligonucleotides provide an important tool to understand how the natural substrate works as well as how to improve their biochemical and biological properties as potential therapeutics and diagnostics. Our carba-LNA (2',4'-carba-bridged Locked Nucleic Acid) modified oligo-DNA or -RNA have been found to be useful to modulate oligo-RNA and -DNA activity. LÄS MER