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Visar resultat 1 - 5 av 117 avhandlingar som matchar ovanstående sökkriterier.
1. Utilization of single-cell RNA-Seq and genome-scale modeling for investigating cancer metabolism
Sammanfattning : Cancer remains a leading cause of death worldwide, and its dysregulated metabolism is a promising target for therapy. However, metabolism is complex to study – the metabolism of a cell involves the interplay of thousands of chemical reactions that are combined in different ways across tissues and cell types. LÄS MER
2. Integration of RNA and protein expression profiles to study human cells
Sammanfattning : Cellular life is highly complex. In order to expand our understanding of the workings of human cells, in particular in the context of health and disease, detailed knowledge about the underlying molecular systems is needed. LÄS MER
3. Persistent infection by Yersinia pseudotuberculosis
Sammanfattning : Enteropathogenic Yersinia species can infect many mammalian organs such as the small intestine, cecum, Peyer’s patches, liver, spleen, and lung and cause diseases that resemble a typhoid-like syndrome, as seen for other enteropathogens. We found that sublethal infection doses of Y. LÄS MER
4. Computational methods for analysis and visualization of spatially resolved transcriptomes
Sammanfattning : Characterizing the expression level of genes (transcriptome) in cells and tis- sues is essential for understanding the biological processes of multicellular or- ganisms. RNA sequencing (RNA-seq) has gained traction in the last decade as a powerful tool that provides an accurate quantitative representation of the transcriptome in tissues. LÄS MER
5. Sex, Molecules, and Gene control : Ecophysiological and evolutionary aspects of key sponge species from Antarctic shallow waters and the deep sea
Sammanfattning : Very little is known about the ecophysiological aspects of Porifera (sponges) from Antarctica and North Atlantic, even though they are keystone components of these habitats. Being the earliest diverging metazoan lineage, sponges also play a fundamental role in our understanding of animal evolution. LÄS MER