Sökning: "RNA-binding domains"

Visar resultat 1 - 5 av 19 avhandlingar innehållade orden RNA-binding domains.

1. 1. Adapting to succeed : Post-transcriptional gene regulation in Salmonella

   Författare :Alisa Rizvanovic; Erik Holmqvist; Fabien Darfeuille; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Salmonella; gene regulation; post-transcriptional regulation; RNA-binding protein; ProQ; sRNA; flagella; motility; antibiotic persistence;

   Sammanfattning : Salmonella are zoonotic pathogens of worldwide economic and health importance. Both during life outside and inside the host, these pathogens are subject to continuously changing environmental conditions, such as temperature changes, acid stress, nutrient limitations, and others. LÄS MER

3. 2. Functional studies of the Quaking gene : Focus on astroglia and neurodevelopment

   Författare :Katarzyna Radomska; Elena Jazin; Pertti Panula; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; QKI; RNA-binding protein; astrocyte; interferon; GFAP; neurodevelopment; zebrafish; neural progenitor cell;

   Sammanfattning : The RNA-binding protein Quaking (QKI) plays a fundamental role in post-transcriptional gene regulation during mammalian nervous system development. QKI is well known for advancing oligodendroglia differentiation and myelination, however, its functions in astrocytes and embryonic central nervous system (CNS) development remain poorly understood. LÄS MER

4. 3. Eukaryotic Ribosome Biogenesis : Focus on the function of the assembly factor Mrd1p

   Författare :Åsa Segerstolpe; Lars Wieslander; Susan Gerbi; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ribosome biogenesis; nucleolus; pre-rRNA processing; RNA-binding proteins; Mrd1; Molecular Biology; molekylärbiologi;

   Sammanfattning : The ribosome, the protein factory of the cell, is essential for all life forms. The ribosome is a large RNA-protein machine. It is built in a complex, multi-step process that involves a large number of accessory trans-acting factors and the synthesis consumes a considerable part of the cellular energy. LÄS MER

5. 4. A Genetic Survey of the Pathogenic Parasite Trypanosoma cruzi

   Författare :Anh-Nhi Tran; Lena Åslund; John Kelly; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; Trypanosoma cruzi; Chagas ; gene discovery; EST; sequencing; DGC3; repeats; gene family; CL Brener; trypanothione synthetase; TcTRS locus; alleles; polymorphism; RNA-binding protein; TcPTB; stage-specific expression; Genetik; Genetics; Genetik; medicinsk genetik; Medical Genetics;

   Sammanfattning : Trypanosoma cruzi, the causative agent of Chagas´ disease, is an evolutionarily ancient species with distinct biological and immunological characteristics. A fundamental understanding of the basic biology of the parasite is necessary in order to develop reliable therapeutic and prophylactic agents against T. cruzi. We have, as a part of the T. LÄS MER

7. 5. The Modular Domain Structure of ASF/SF2: Significance for its Function as a Regulator of RNA Splicing

   Författare :Vita Dauksaite; Göran Akusjärvi; Javier Caceres; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; pre-mRNA splicing; alternative splicing; splicing regulation; SR proteins; ASF SF2; modular domains; adenovirus; MLTU L1; E1A; MS2; Molekylärbiologi; Molecular biology; Molekylärbiologi;

   Sammanfattning : ASF/SF2 is an essential splicing factor, required for constitutive splicing, and functioning as a regulator of alternative splicing. ASF/SF2 is modular in structure and contains two amino-terminal RNA binding domains (RBD1 and RBD2), and a carboxy-terminal RS domain. LÄS MER