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Visar resultat 1 - 5 av 6 avhandlingar som matchar ovanstående sökkriterier.

1. 1. RNA-based Prognostic Markers in Chronic Lymphocytic Leukemia

   Författare :Marie Sevov; Richard Rosenquist; Mahmoud Mansouri; Denis Alexander; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chronic lymphocytic leukemia; prognostic markers; RNA-based markers; LPL; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; Haematology; Hematologi; Medical Science; Medicinsk vetenskap;

   Sammanfattning : Chronic lymphocytic leukemia (CLL) is a heterogeneous disease where a significant proportion of patients will develop an aggressive disease. Today, the mutational status of the immunoglobulin heavy variable (IGHV) genes is one of the strongest prognostic markers in CLL, where unmutated IGHV genes correlate with poor outcome. LÄS MER

3. 2. Assessment of Novel Molecular Prognostic Markers in Chronic Lymphocytic Leukemia

   Författare :Mohamed Arifin Bin Kaderi; Richard Rosenquist Rosenquist; Mahmoud Mansouri; Mattias Jansson; Denis Alexander; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chronic lymphocytic leukemia; prognostic markers; single nucleotide polymorphisms; RNA-based markers; Medical genetics; Medicinsk genetik; Genetics; Genetik; Clinical genetics; Klinisk genetik; Medical laboratory science; Medicinsk laboratorievetenskap; Oncology; Onkologi; Haematology; Hematologi; Clinical Genetics; Klinisk genetik; Molekylär medicin; Molecular Medicine; Oncology; Onkologi; Medicin; Medicine; Medical Genetics; Medicinsk genetik;

   Sammanfattning : The clinical course of chronic lymphocytic leukemia (CLL) is highly heterogeneous, which has prompted the search for biomarkers that can predict prognosis in this disease. The IGHV gene mutation status and certain genomic aberrations have been identified as reliable prognostic markers of clinical outcome for this disorder. LÄS MER

4. 3. Summer cyanobacterial blooms in the Baltic Sea - implications for copepod recruitment

   Författare :Hedvig Hogfors; Sture Hansson; Wim Kimmerer; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cyanobacteria; Calanoid copepods; Food web interactions; Harmful algae blooms; Zooplankton; Nodularin; Allelopathy; Baltic Sea; Biochemical markers; RNA-based indices; Acidification; Global Climate Change; Marine Ecology; marin ekologi;

   Sammanfattning : During summer, the Baltic Sea is subjected to the world’s largest cyanobacterial blooms. These blooms are linked to eutrophication and raise many questions concerning their effects on the ecosystem. To understand their impacts on the food web dynamics, it is essential to assess growth responses of grazers to these cyanobacteria. LÄS MER

5. 4. Zooplankton growth and trophic linkages : Implications for fish feeding conditions in the Baltic Sea

   Författare :Towe Holmborn; Elena Gorokhova; Sture Hansson; Ilppo Vuorinen; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; AARS activity; biochemical markers; Clupea harengus; copepod physiology; food web interactions; non-indigenous species; RNA-based indices; Sprattus sprattus; stable isotopes; Marine ecology; Marin ekologi; Marine Ecology; marin ekologi;

   Sammanfattning : The aim of this Thesis was to improve our understanding and assessment of feeding conditions for zooplanktivorous fish in the Baltic Sea.We investigated (papers I, II) the usefulness of biochemical proxies for assessments of growth and metabolic rates in the dominant Baltic copepod Acartia bifilosa. LÄS MER

7. 5. Prognostic markers and DNA methylation profiling in lymphoid malignancies

   Författare :Sujata Bhoi; Richard Rosenquist Brandell; H Denis Alexander; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lymphoid malignancies; CLL; MCL; prognostic markers; micro-RNA; methylation; stereotyped subsets;

   Sammanfattning : In recent years, great progress has been achieved towards identifying novel biomarkers in lymphoid malignancies, including chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL), at the genomic, transcriptomic and epigenomic level for accurate risk-stratification and prediction of treatment response. In paper I, we validated the prognostic relevance of a recently proposed RNA-based marker in CLL, UGT2B17, and analyzed its expression levels in 253 early-stage patients. LÄS MER