Sökning: "RNA Polymerase II metabolism"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden RNA Polymerase II metabolism.

1. 1. Expanding role of caveolae in control of adipocyte metabolism : proteomics of caveolae

   Författare :Nabila Aboulaich; Peter Strålfors; Alexander Vener; Hans Jörnvall; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diabetes; Insulin signalling; Fatty acid metabolism; Proteomics; Mass spectrometry; Cell and molecular biology; Cell- och molekylärbiologi;

   Sammanfattning : The primary function of adipose tissue is to store energy in the form of triacylglycerol, which is hydrolyzed to fatty acids to supply other tissues with energy. While insulin promotes the storage of triacylglycerol, catecholamines stimulate its hydrolysis. LÄS MER

3. 2. The RNA exosome and the maintenance of genome integrity

   Författare :Judit Domingo Prim; Neus Visa; Andrés Aguilera; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; EXOSC10; RRP6; DNA damage; diRNA; DDRNA; DNA end resection; homologous recombination; molekylär biovetenskap; Molecular Bioscience;

   Sammanfattning : The RNA exosome is a ribonucleolytic complex that acts on different RNA substrates and plays important roles in RNA metabolism. In recent years, the synthesis and the processing of RNA have been directly linked to the integrity of the genome. LÄS MER

4. 3. Carbohydrate-restricted diets in diabetes and the irritable bowel syndrome. Effects on symptoms, inflammation and microbiota

   Författare :Clara Nilholm; Internmedicin - epidemiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetes; IBS; carbohydrates; metabolism; inflammation; microbiota; miRNA;

   Sammanfattning : This doctoral thesis explores the effects of carbohydrate(CHO)-restricted diets on symptoms and disease-related variables in type 2 diabetes mellitus (T2DM) and the irritable bowel syndrome (IBS). Aims were to examine the effects of (I) the moderately-low CHO Okinawan-based Nordic diet on anthropometry and metabolism and microbiota-related, inflammatory, and cognitive parameters in T2DM, and (II) the low-CHO starch- and sucrose reduced diet on gastrointestinal (GI) symptoms, dietary intakes, inflammatory parameters, microbiota and microribonucleic acid (miRNA) expression in IBS. LÄS MER

5. 4. Molecular mechanisms for transcription in mammalian mitochondria

   Författare :Martina Gaspari; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :mitochondria; oxidative phosphorylation; mtDNA; transcription; TFAM; TFB1M TFB2M; POLRMT; promoter recognition; CSB II;

   Sammanfattning : The circular double stranded mitochondrial genome (mtDNA), which is about 16,600 bp in humans and 16,300 bp in mice, encodes 13 of the -90 different proteins present in the respiratory chain of mammalian mitochondria. The remaining components of the respiratory chain are encoded by nuclear genes and imported into the mitochondrial network. LÄS MER

7. 5. Genetic and Genomic Analysis of Transcriptional Regulation in Human Cells

   Författare :Mehdi Motallebipour; Claes Wadelius; Gunnar Westin; Dirk Schübeler; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Transcription; ChIP-chip; ChIP-seq; genome-wide; transcription factors; microsatellite; epigenetic; Medical genetics; Medicinsk genetik;

   Sammanfattning : There are around 20.000 genes in the human genome all of which could potentially be expressed. However, it is obvious that not all of them can be active at the same time. Thus, there is a need for coordination achieved through the regulation of transcription. LÄS MER