Sökning: "RANKL"

Visar resultat 21 - 25 av 36 avhandlingar innehållade ordet RANKL.

  1. 21. Studies on the role of anti-citrullinated protein antibodies in rheumatoid arthritis

    Författare :Aase Eline Haj Hensvold; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Anti-citrullinated protein antibodies (ACPA) are highly specific for rheumatoid arthritis (RA) and present in about two thirds of all patients at diagnosis. They can be detected already before disease onset and have direct pathogenic effect mediated partly through the Fc (fragment crystalizable) portion with attached Fc-glycan structure. LÄS MER

  3. 22. Identifying and targeting vulnerabilities in cancers that metastasize to the bone and bone marrow

    Författare :Adele Mirna Alchahin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Evolving technologies enable scientist to ask and seek answers to advanced questions, above and beyond. During the past decade single-cell RNA sequencing (scRNA-seq) has revolutionized our understanding of biology, in particular within cancer research. LÄS MER

  4. 23. Estrogen and raloxifene in experimental arthritis and osteoporosis

    Författare :Caroline Jochems; Göteborgs universitet; []
    Nyckelord :rheumatoid arthritis; osteoporosis; estrogen; raloxifene; mice;

    Sammanfattning : ABSTRACT In postmenopausal rheumatoid arthritis (RA), both the estrogen deficiency and the inflammatory disease contribute to the development of generalized osteoporosis. This leads to an increased risk of fracture, with high morbidity and mortality. More than 50% of women with postmenopausal RA suffer from osteoporosis. LÄS MER

  5. 24. A methodological platform to study molecular biocompatibility of biomaterials. Experimental and clinical studies

    Författare :Maria Lennerås; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Osseointegration; titanium; inflammation; cell recruitment; cell adhesion; bone regeneration; bone remodelling; gene expression; immunohistochemistry; histomorphometry; removal torque; ultrastructure; FACS; protein profiling; transfemoral amputation; abutment; percutaneous; bacteria; clinical signs;

    Sammanfattning : The aim of this project was to develop a methodological platform in order to advance our scientific understanding of the mechanisms of osseointegration. Screw-shaped, titanium implants, with different surface properties, were inserted in the rat tibia, or incubated in mono- or co-culture of human monocytes and MSCs. LÄS MER

  7. 25. Infection biology of Chlamydia pneumoniae

    Författare :Leslie Bailey; Sven Bergström; Peter Nordström; Anders Waldenström; Kenneth Fields; Umeå universitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Chlamydia pneumoniae; Type three secretion system; Bone; Medicine; Medicin;

    Sammanfattning : There are two main human pathogens in the family of Chlamydiaceae. Different serovars of Chlamydia trachomatis cause sexually-transmitted disease and eye infections whereas C. pneumoniae (TWAR) is a common cause of community-acquired respiratory infection. LÄS MER