Sökning: "RANK KO"
Hittade 2 avhandlingar innehållade orden RANK KO.
1. Development of Novel Models for Studying Osteoclasts
Sammanfattning : This thesis focuses on developing and characterizing novel models for studying osteoclasts with an emphasis on how mutations abolishing osteoclastic acidification affect osteoclast signaling and bone remodeling, as well as how to treat patients bearing these rare mutations. Bone remodeling is under normal circumstances a tightly balanced process where resorption of bone by osteoclasts is followed by adequate amounts of bone formation by osteoblasts. LÄS MER
2. The role of mechanical loading, sex and TRAP/ACP5 on bone properties
Sammanfattning : A well-balanced bone structure involves a balanced role of the osteoclasts, osteoblasts, and osteocytes. The balance is maintained by different internal and external factors like calcium demands, the immune system and its cytokines, or mechanical loading. LÄS MER