Sökning: "RAF"

Visar resultat 6 - 10 av 38 avhandlingar innehållade ordet RAF.

  1. 6. The Effects of SSRI Treatment on Human Placenta and Embryo

    Författare :Helena Kaihola; Helena Åkerud; Inger Sundström-Poromaa; Jocelien Olivier; Olav Spigset; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antenatal depression; embryo; embryo development; fluoxetine; gene expression; NGF; placenta; protein expression; Raf-1; ROCK; signaling pathways; SSRI; Medicinsk vetenskap; Medical Science; Obstetrik och gynekologi; Obstetrics and Gynaecology;

    Sammanfattning : During pregnancy, 4 - 7% of women suffer from major depressive disorder. When antidepressive treatment is needed, selective serotonin reuptake inhibitors (SSRIs) are the most commonly used. Although severe complications from SSRI treatment are rare, association with a number of adverse pregnancy and fetal outcomes has been found. LÄS MER

  3. 7. Receptor Upregulation and MAPK Activity in Arteries and Bronchi Following Secondhand Smoke Exposure

    Författare :Lei Cao; Lund Medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; coronary arteries; cerebral arteries; 5-hydroxytryptamine receptor; endothelin receptor; secondhand smoke exposure; bronchi;

    Sammanfattning : Cigarette smoking is a major risk factor for cardiovascular and respiratory diseases. Contractile receptor changes have been observed in several vascular diseases. The intracellular mitogen activated protein kinase (MAPK) signaling pathways are suggested to be associated with receptor upregulation. LÄS MER

  4. 8. Studies of induced transcription in response to an activated Ha-ras, TPA and UV radiation in keratinocytes

    Författare :Mats Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :keratinocytes; Ha-ras; ultraviolet radiation; transcription factor; TPA; NF-kB;

    Sammanfattning : The mutational activation of the Ha-ras gene in keratinocytes has been shown to occur during the initiation step in the mouse skin model for multistage carcinogenesis. Skin tumor promoters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) and ultraviolet radiation (UVR) stimulate a selective outgrowth of initiated keratinocytes to form benign tumours (papillomas). LÄS MER

  5. 9. Activating proto-oncogene mutations in human cutaneous melanoma

    Författare :Katarina Omholt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cutaneous melanoma arises from melanocytes located in the basal layer of the epidermis. The disease is known to progress through well-defined steps: 1) common nevus; 2) dysplastic nevus; 3) radial growth phase (RGP) primary melanoma; 4) vertical growth phase (VGP) primary melanoma; and 5) metastatic melanoma. LÄS MER

  7. 10. Fibroblast growth factor-induced signal transduction

    Författare :Peter Klint; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Biokemi; Biochemistry; Biokemi; molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : Fibroblast growth factors (FGFs) evoke cellular responses by binding to FGF receptors (FGFRs). FGFRs are cell surface expressed membrane-spanning receptors with intrinsic stimulatable tyrosine kinase activity. This thesis describes the cell proliferation or differentiation. LÄS MER