Sökning: "RADICAL ENZYMES"

Visar resultat 1 - 5 av 48 avhandlingar innehållade orden RADICAL ENZYMES.

  1. 1. Quantum chemical studies of radical enzymes

    Författare :Fahmi Himo; Robert J Deeth; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Theoretical Physics; teoretisk fysik;

    Sammanfattning : .... LÄS MER

  3. 2. Allosteric Regulation and Radical Transfer in Ribonucleotide Reductase

    Författare :Karl-Magnus Larsson; Pär Nordlund; Derek Logan; Roger Kornberg; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; allosteric regulation; substrate specificity; ribonucleotide reductase; radical; Biochemistry; Biokemi;

    Sammanfattning : The stability of biological life over time requires that the integrity of the genetic material of an organism, the genome, be maintained as it is passed on from one generation to the next. All known cellular life has DNA-based genomes, which are duplicated before each cell division in a process called replication. LÄS MER

  4. 3. Helicobacter pylori associated effects on inflammatory radical formation and angiotensin II receptors in the stomach

    Författare :Anders Elfvin; Göteborgs universitet; []
    Nyckelord :Helicobacter pylori; Mongolian gerbil; gastric adenocarcinoma; nitro-radical; iNOS; nitric oxide; nitrotyrosine; oxy-radical; myeloperoxidase; angiotensin II; AT1R; AT2R;

    Sammanfattning : Helicobacter pylori infection of the stomach always results in mucosal inflammation and a marked systemic immune response. Despite the profound host defence reactions the bacterium avoids elimination and persists in the mucosa. This results in chronic inflammation and an increased risk for peptic ulcers and adenocarcinoma. LÄS MER

  5. 4. Theoretical Modeling of Enzyme Catalysis with Focus on Radical Chemistry

    Författare :Vladimir Pelmenschikov; Per E. M. Siegbahn; Tim Clark; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; density functional theory; enzyme catalysis; radical chemistry; zinc-containing peptidase; methyl-coenzyme M reductase; ribonucleotide reductase; superoxide dismutase; Quantum chemistry; Kvantkemi;

    Sammanfattning : Hybrid density functional theory (DFT) B3LYP method is applied to study the four diverse enzyme systems: zinc-containing peptidases (thermolysin and stromelysin), methyl-coenzyme M reductase, ribonucleotide reductases (classes I and III), and superoxide dismutases (Cu,Zn- and Ni-dependent enzymes). Powerfull tools of modern quantum chemistry are used to address the questions of biological pathways at their molecular level, proposing a novel mechanism for methane production by methyl-coenzyme M reductase and providing additional insights into hydrolysis by zinc peptidases, substrate conversion by ribonucleotide reductases, and biological superoxide dismutation. LÄS MER

  7. 5. Structural and functional investigation of underexplored carbohydrate-active enzyme families

    Författare :Andrea Seveso; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; carbohydrate-active enzymes; lytic polysaccharide monooxygenase; plant biomass degradation; copper radical oxidases; carbohydrate esterase; protein structure determination; protein structure prediction;

    Sammanfattning : The known consequences of the current fossil-based economy require a transition towards a bio-based economy. Development of biorefineries in which plant biomass can be utilized as a renewable source of energy and building blocks to produce both commodities and high-value products, is a key step in this transition. LÄS MER