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Visar resultat 1 - 5 av 25 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Identification of Unique Hematopoietic Stem Cell Properties

    Författare :Jens Nygren; Lunds universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kardiovaskulära systemet; Cardiovascular system; Hematologi; extracellulära vätskor; Haematology; extracellular fluids; cell cycle; fusion; transdifferentiation; plasticity; Medicine human and vertebrates ; Medicin människa och djur ; quiescence; hematopoietic stem cell; self-renewal;

    Sammanfattning : Hematopoietic stem cells (HSC) are sufficient and required for life long production of all blood cell lineages. Steady state HSCs are largely quiescent and we demonstrate that the kinetics of HSC cell cycling are slower compared to more committed progenitor cells also during expansion and self-renewal ex vivo and in physiological conditions. LÄS MER

  3. 2. A Purkinje cell Timing Mechanism. On the Physical Basis of a Temporal Duration Memory

    Författare :Fredrik Johansson; Associativ inlärning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cerebellum; Purkinje cell; Timing; Temporal; Memory; Eyeblink conditioning; mGluR7; Kir3; GIRK;

    Sammanfattning : The standard view of neural signaling is that a neuron can influence its target cell by exciting or inhibiting it. Learning is thought to involve strengthening or weakening synaptic connections. For most behaviors, the brain must learn to produce precisely timed activity patterns. LÄS MER

  4. 3. Novel Interactors of X-linked Inhibitor of Apoptosis Protein : Expression and Effects on Tumor Cell Death

    Författare :Håkan Steen; Dan Lindholm; Bertrand Joseph; Uppsala universitet; []
    Nyckelord :Neurobiology; XIAP; tumor cell death; apoptosis; caspases; basic helix-loop-helix protein; Neurobiologi;

    Sammanfattning : Programmed cell death, or apoptosis, has during the last decade received a lot of attention due to its involvement in a large number of pathological conditions. Since death is always irreversible, it is important for cells to fully control the initiation and execution of this process. LÄS MER

  5. 4. An Associative Memory Trace in the Cerebellar Cortex

    Författare :Dan-Anders Jirenhed; Associativ inlärning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsykologi; neurofysiologi; neurophysiology; Neurologi; neuropsychology; Classical Conditioning; Cerebellum; Purkinje cell; Physiology; Fysiologi; Neurology;

    Sammanfattning : Classical conditioning of motor responses, e.g., the eyeblink response, depends on the cerebellum. In the theoretical works of David Marr (1969) and James Albus (1971), it was proposed that Purkinje cells in the cerebellar cortex learn to associate the neutral conditioned stimulus with the response. LÄS MER

  7. 5. The Cerebello-Olivary Feedback System

    Författare :Fredrik Bengtsson; Neurofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsykologi; neurofysiologi; neurophysiology; Neurology; neuropsychology; Fysiologi; Physiology; Cerebellum; Purkinje cell; Inferior olive; Neurologi; Nucleo-olivary; Climbing fibre.; Deep cerebellar nuclei;

    Sammanfattning : The pathway from the deep cerebellar nuclei to the inferior olive, the nucleo-olivary pathway, is known to be inhibitory. The physiological and temporal properties, as well as the localisation, of the nucleo-olivary pathway were characterised in the decerebrate ferret. LÄS MER