Sökning: "Pulmonary vascular dysfunction"

Visar resultat 1 - 5 av 22 avhandlingar innehållade orden Pulmonary vascular dysfunction.

1. 1. Hemodynamic Effects of Lung Function Optimization in Experimental Acute Respiratory Distress Syndrome

   Författare :Arnoldo Santos; Anders Larsson; Fernando Suarez-Sipmann; John Marini; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute respiratory distress syndrome; Lung protective ventilation; Mechanical ventilation; Open lung approach; Pulmonary heart disease; Pulmonary vascular mechanics; Pulmonary vascular dysfunction; Pulse wave analysis; Right ventricular dysfunction; Anestesiologi och intensivvård; Anaesthesiology and Intensive Care; Fysiologi; Physiology;

   Sammanfattning : Acute Respiratory Distress Syndrome (ARDS) is a severe pulmonary inflammation affecting thousands of patients every year in Sweden and has a mortality of 30-50%. Mechanical ventilation (MV) is usually necessary, but could per se augment the inflammation and contribute to mortality. LÄS MER

3. 2. Vascular remodeling in pulmonary hypertension

   Författare :Ya-Ting Chang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Pulmonary hypertension (PH) is a progressive obliterative vasculopathy with multifactorial etiology and high mortality rate. Endothelial dysfunction, excessive vascular remodeling, inflammation and in situ thrombosis contribute to increased vascular resistance and gradual occlusion of pulmonary vessels. LÄS MER

4. 3. Vardenafil and methylarginines in pulmonary hypertension

   Författare :Anna Sandqvist; Gerhard Wikström; Jörn Schneede; Amrita Ahluwalia; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; vardenafil; pulmonary hypertension; pharmacokinetics; haemodynamics; right heart catheterization; adenosine; dimethylarginines; phosphodiesterase type 5 inhibitors; endothelin receptor antagonists; klinisk farmakologi; Clinical Pharmacology;

   Sammanfattning : Background: Pulmonary hypertension (PH) is a rare condition characterized by endothelial dysfunction and vascular remodelling, leading to increased pulmonary vascular resistance (PVR) and right ventricular heart failure. Endothelial dysfunction is associated with an imbalance between vasoconstrictor compounds, such as endothelin and thromboxane A2, and vasodilator compounds, such as prostacyclin and nitric oxide (NO). LÄS MER

5. 4. Endothelin in the pulmonary circulation with special reference to hypoxic pulmonary vasoconstriction

   Författare :Peter Holm; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :bosentan; BMS-182874; ; BQ-123; BQ-788; endothelin; endothelium; hypoxia; hypoxic pulmonary vasoconstriction; pulmonary hypertension; receptor antagonism; TBC 11251.;

   Sammanfattning : A number of substances originating from the pulmonary endothelium have recently been found to be involved in the regulation of pulmonary vascular tone. Accumulating evidence suggests that endothelial dysfunction contributes to pulmonary hypertension, an important clinical problem often associated with hypoxemia. LÄS MER

7. 5. Right ventricular function in pulmonary embolism

   Författare :Riikka Rydman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Patients with pulmonary embolism (PE) and right ventricular (RV) dysfunction are known to be at risk of in-hospital clinical worsening and PE-related mortality. Even in patients with a preserved systemic arterial pressure, the RV dysfunction indicates a higher risk, thus affecting the patients’ level of care and the therapeutic approach. LÄS MER