Sökning: "PtdIns 4"
Visar resultat 6 - 9 av 9 avhandlingar innehållade orden PtdIns 4.
6. Phosphatidylinositol phosphate kinases in the moss Physcomitrella patens
Sammanfattning : Phosphatidylinositol(4,5)bisphosphate, [PtdIns(4,5)P2], is a signalling lipid which is involved in many important processes in animal cells such as cytoskeleton organization, intracellular vesicular trafficking, secretion, cell motility, regulation of ion channels, and nuclear signalling pathways. In contrast to the animal field, much less is known about the roles of PtdIns(4,5)P2 and its synthesizing enzyme, phosphatidylinositol phosphate kinase (PtdInsP kinase), in plants. LÄS MER
7. Theoretical Studies of Protein-Ligand Interactions
Sammanfattning : The protein-ligand interaction is an important issue in rational drug design and protein function research. This thesis focuses on the study of protein-ligand interactions using various molecular modeling methods, which are used in combination to predict the binding modes and calculate the binding free energies of several important protein-ligand systems, as summarized below. LÄS MER
8. Epac2 signaling at the β-cell plasma membrane
Sammanfattning : Secretion of appropriate amounts of insulin from pancreatic β-cells is crucial for glucose homeostasis. The β-cells release insulin in response to glucose and other nutrients, hormones and neurotransmitters, which trigger intracellular signaling cascades, that result in exocytotic fusion of insulin-containing vesicles with the plasma membrane. LÄS MER
9. A multifaceted study of the receptor tyrosine kinase Axl with focus on Renal Cell Carcinoma
Sammanfattning : The present investigation is a multifaceted study of the receptor tyrosine kinase Axl, whose overexpression and activation is implicated in several human malignancies, with focus on renal cell carcinoma (RCC). At first, our main interest concerned the intracellular Axl interactor named Tensin2 (Tns2) and its family member Tensin3 (Tns3). LÄS MER