Sökning: "Proto-Oncogene Proteins"

Visar resultat 1 - 5 av 16 avhandlingar innehållade orden Proto-Oncogene Proteins.

1. 1. Immunological aspects of papillary thyroid carcinoma

   Författare :Steven D. Lucas; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Papillary thyroid carcinoma; immunology; tumor antigens; RET proto-oncogene; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

   Sammanfattning : Papillary thyroid carcinoma (PTC) is a puzzling disease. Although approximately 70% of patients with PTC have regional lymph node metastases at initial surgery, the long term survival is over 95%. LÄS MER

3. 2. New Roles of Filamins in Cell Signaling, Transcription and Organ Development

   Författare :Xianghua Zhou; Göteborgs universitet; []
   Nyckelord :filamins; cell movement; hypoxia-inducible factor 1; proto-oncogene proteins c-met; mice; knockout; F-actin-binding proteins; integrins; GTB phosphohydrolases; genetic diseases; inborn; vascular endothelial cell growth factor A; Smad2 protein; hepatocyte growth factor; cartilage; osteogenesis; neovascularization; neoplasm metastasis;

   Sammanfattning : Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin networks and link them to cellular membranes. They integrate cell architectural and signaling functions and are essential for cell locomotion and development. LÄS MER

4. 3. Genes and proteins controlled by cGMP-PKG during retinal degeneration

   Författare :Jiaming Zhou; Lund Oftalmologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; retinal degeneration; cell death; cGMP-PKG; organotypic explant culture; RNA sequencing; mass spectrometry;

   Sammanfattning : prevalence was reported as 1:3000-4000 worldwide, making it the main reason for blindness in the working population in industrial countries. The mutations of over 70 genes have been related to this genetic disorder, and there is generally no effective treatment, except for gene therapy for the RPE65 mutations. LÄS MER

5. 4. Structure and function in c-Myc and Grx4 : two key proteins involved in transcriptional activation and oxidative stress

   Författare :Malin Fladvad; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The proto-oncogene c-myc is critical for growth and development and deregulation of c-myc expression affects the initiation and expansion of a wide range of human cancers, many of them aggressive. cMyc is a multi-domain protein, where it's C-terminal basic helix-loop-helix leucine zipper (bHLH-Zip) domain heterodimerizes with Max to accomplish gene regulatory activity. LÄS MER

7. 5. Glial cell line-derived neurotrophic factor : expression patterns, neuronal transport, regulation, effects, and receptor dependence

   Författare :Andreas C Tomac; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :glial cell line-derived neurotrophic factor GDNF ; neurturin NTN ; persephin PSP ; c Ret proto oncogene Ret ; GPI-linked receptors for the GDNF ligand family GFRas ; transforming growth factor-B TGFB ; Parkinson s disease PD ; dopaminergic DA neurons;

   Sammanfattning : Background: The mammalian nervous system depends upon trophic proteins for survival, growth and adult maintenance. These trophic factors have also been considered as potential therapeutic agents for treating human neurodegenerative disorders. LÄS MER