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Visar resultat 1 - 5 av 430 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Dementia Proteomics

   Författare :Julia Remnestål; Peter Nilsson; Anna Månberg; Pieter Jelle Visser; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dementia; Proteomics; Alzheimer s disease; Frontotemporal dementia; Antibody array; Suspension bead array; Cerebrospinal fluid; Protein profiling; Biomarker discovery; Bioteknologi; Biotechnology;

   Sammanfattning : The term dementia encompass a number of conditions arising as a consequence of tissue degeneration in the brain. This degeneration is caused by molecular events occurring on a cellular level including inflammation, defective waste disposal and accumulation of insoluble proteins and peptides. LÄS MER

3. 2. Functional proteomics : Generation and analysis of cDNA-encoded proteins

   Författare :Susanne Gräslund; KTH; []
   Nyckelord :functional genomics; functional proteomics; gene characterization; E. coli expression; affinity purification; immunolocalization; mouse testis; spermatogenesis; rabbit antibodies; affibody; tektin; Anaphase-promoting complex or cyclosome.;

   Sammanfattning : .... LÄS MER

4. 3. Expanding role of caveolae in control of adipocyte metabolism : proteomics of caveolae

   Författare :Nabila Aboulaich; Peter Strålfors; Alexander Vener; Hans Jörnvall; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diabetes; Insulin signalling; Fatty acid metabolism; Proteomics; Mass spectrometry; Cell and molecular biology; Cell- och molekylärbiologi;

   Sammanfattning : The primary function of adipose tissue is to store energy in the form of triacylglycerol, which is hydrolyzed to fatty acids to supply other tissues with energy. While insulin promotes the storage of triacylglycerol, catecholamines stimulate its hydrolysis. LÄS MER

5. 4. Machine Learning methods in shotgun proteomics

   Författare :Patrick Truong; Lukas Käll; Peter Nilsson; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mass spectrometry protein summarization Bayesian hierarchical modelling label-free quantification data-independent acquisition mass spectrometry; benchmark mathematical methods; transformers; computational proteomics; proteomics; bioinformatics; bert; ms2 intensity; probabilistic modelling; Biotechnology; Bioteknologi;

   Sammanfattning : As high-throughput biology experiments generate increasing amounts of data, the field is naturally turning to data-driven methods for the analysis and extraction of novel insights. These insights into biological systems are crucial for understanding disease progression, drug targets, treatment development, and diagnostics methods, ultimately leading to improving human health and well-being, as well as, deeper insight into cellular biology. LÄS MER

7. 5. Neuropeptidomics – Expanding Proteomics Downwards

   Författare :Marcus Svensson; Per Andrén; Per Svenningsson; Jonathan Sweedler; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical pharmacology; proteomics; peptidomics; mass spectrometry; neuropeptide; chromatography; Farmaceutisk farmakologi; PHARMACY; FARMACI;

   Sammanfattning : Biological function is mainly carried out by a dynamic population of proteins which may be used as markers for disease diagnosis, prognosis, and as a guide for effective treatment. In analogy to genomics, the study of proteins is called proteomics and it is generally performed by two-dimensional gel electrophoresis and mass spectrometric methods. LÄS MER