Sökning: "Proteoglycans"

Visar resultat 21 - 25 av 144 avhandlingar innehållade ordet Proteoglycans.

  1. 21. Articular cartilage proteoglycan biosynthesis and sulfation

    Författare :Chengjuan Qu; Mikko Lammi; Heikki Helminen; Juha Töyräs; Anna-Marja Säämänen; Finland Kuopio University of Kuopio Anatomy Department of Biomedicine; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Cartilage; Chondrocytes metabolism; Chondroitin sulfates; Glycosaminoglycans; Osteoarthritis; Proteoglycans; Glucosamine; Sulfation; Biochemistry; biokemi; cellforskning; cell research; Orthopaedics; ortopedi;

    Sammanfattning : Glucosamine (GlcN) and glucosamine sulfate (GS) have been used to treat the patients with osteoarthritis(OA) as a disease-modifying agent. Previousin vitro studies have focused on the effects of GlcN or GSon cartilage metabolism, whereas in vivo studies have investigated their potential for the treatment of OA. LÄS MER

  3. 22. Extracellular matrix in atherosclerotic plaques: its role in plaque stability

    Författare :Christoffer Tengryd; Kardiovaskulär forskning - translationella studier; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Extracellular matrix; Laminin; Collagen; Proteoglycans; Atherosclerosis; Carotid plaque; TGF-β;

    Sammanfattning : Atherosclerosis is a systemic disease affecting the large arteries caused by the accumulation of lipids in the vessel wall. Cardiovascular disease due to atherosclerosis is today the most common cause of death globally through its end consequences: myocardial infarctions and stroke. LÄS MER

  4. 23. Adaptation to microenvironmental stress in glioblastoma. Mechanistic studies and potential targets

    Författare :Myriam Cerezo-Magaña; Tumörmikromiljö; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Glioblastoma; Tumor microenvironment; EVs; Proteoglycans; Tumor Surfaceome;

    Sammanfattning : Although the overall mortality in cancer is steadily decreasing, major groups of patients still respond poorly to available treatments. The key clinical challenge addressed in the present thesis work relates to the inherent adaptive capacity of glioblastoma (GBM) tumors, resulting in treatment resistance and dismal prognosis. LÄS MER

  5. 24. Degenerative changes of the human temporomandibular joint : A radiological, microscopical, histomorphometrical and biochemical study

    Författare :Lennart Flygare; Göran Isacsson; Lunds universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Synovial Fluid; Temporomandibular Joint Diseases; Proteoglycans; Osteoarthritis; Observer variation; Microscopy; Bone density; Diagnostic properties; Image processing; Tomography; X-ray; Odontology; stomatology; Odontologi; Temporomandibular Joint Diseases; Synovial Fluid; Proteoglycans; Osteoarthritis; Observer variation; Microscopy; Bone density; Diagnostic properties; Image processing; Tomography; X-ray; Odontology; stomatology; Odontologi;

    Sammanfattning : In five autopsy specimen studies human temporomandibular joints were investigated by conventional tomography, macroscopy, and microscopy for degenerative changes, in particular erosive hard-tissue changes.In the microscopical evaluation special attention was paid to the calcified cartilage. LÄS MER

  7. 25. The Entheses of the Medial Meniscns and Ligaments of the Knee Joint : Descriptive and Experimental Studies

    Författare :Jizong Gao; Michael Benjamin; Linköpings universitet; []
    Nyckelord :knee joint; meniscus; ligaments; insertion; enthesis; quantitative morphology; fibrocartilage; cement line; collagens; proteoglycans; nerve fibres; tensile strength; failure mode; transection; refixation; repair; healing; osteoarthrosis; histology; immunohistochemistry; biomechanics; rabbit model; MEDICINE; MEDICIN;

    Sammanfattning : Meniscal injuries are common in sports. Surgical removal of the meniscus to relieve symptoms is associated with a high risk for late knee joint osteoarthrosis and pain. Meniscal repair or replacement has therefore been advocated. LÄS MER