Sökning: "Proteogenomics"

Hittade 5 avhandlingar innehållade ordet Proteogenomics.

  1. 1. Proteogenomic profiling of metastatic melanoma. From protein expression to patient stratification

    Författare :Magdalena Kuras; Malmö Klinisk kemi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proteomics; Proteogenomics; Mass spectromery; Malignant melanoma; Cancer; Tumor biology;

    Sammanfattning : .... LÄS MER

  3. 2. Multi-omics analysis of relapsed acute myeloid leukemia

    Författare :Svea Stratmann; Linda Holmfeldt; Caroline Heckman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute myeloid leukemia AML ; relapse and resistance; next generation sequencing WGS WES ; RNA-sequencing; DNA methylation; HiRIEF LC-MS; proteogenomics; Molekylär medicin; Molecular Medicine;

    Sammanfattning : The prognosis for patients suffering from acute myeloid leukemia (AML) remains unsatisfactory and survival is often measured in months. Although the majority of patients achieve complete remission after aggressive treatment, most of them relapse within a few years. LÄS MER

  4. 3. Cancer proteogenomics : connecting genotype to molecular phenotype

    Författare :Ioannis Siavelis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The central dogma of molecular biology describes the one-way road from DNA to RNA and finally to protein. Yet, how this flow of information encoded in DNA as genes (genotype) is regulated in order to produce the observable traits of an individual (phenotype) remains unanswered. Recent advances in high-throughput data, i.e. LÄS MER

  5. 4. Mass spectrometry based proteomics : data analysis and applications

    Författare :Yafeng Zhu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mass spectrometry (MS) based proteomics has become a widely used high throughput method to investigate protein expression and functional regulation. From being able to study only dozens of proteins, state-of-art MS proteomic techniques are now able to identify and quantify ten thousand proteins. LÄS MER

  7. 5. At the intersection of proteomics and pathology : application of mass spectrometry-based protein quantification to histopathology and antibody validation

    Författare :Fabio Socciarelli; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The paradigm of Precision Medicine relies on the molecular stratification of patients to select “the right patient for the right drug”. The genomic approach has tried to answer this question, but large genomic studies have raised more questions than given answers. LÄS MER