Sökning: "Protein-disulfide isomerase PDI"

Hittade 5 avhandlingar innehållade orden Protein-disulfide isomerase PDI.

  1. 1. Protein disulfide isomerase : function and mechanism in oxidative protein folding

    Författare :Ruoyu Xiao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Protein disulfide isomerase; endoplasmic reticulum; protein folding;

    Sammanfattning : The formation of native intramolecular disulfide bonds is critical for the folding and stability of many secreted proteins. This process involves oxidation of protein thiols to form disulfide bonds as well as rearrangement of any non-native disulfide bonds that might form. LÄS MER

  3. 2. Studies on Redox-proteins and Cytokines in inflammation and Cancer

    Författare :Akter Hossain; Anders Rosén; Christer Lindqvist; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Thioredoxin Trx ; Selenium; Tumor necrosis factor TNF ; Cancer; nflammation; oxidative stress; Protein-disulfide isomerase PDI ; Tumor necrosis factor receptor TNFR ; Medical cell biology; Medicinsk cellbiologi;

    Sammanfattning : The redox state in the cell plays a major role in determining vital functions and its major imbalance can lead to severe cell injury or death. Redox active proteins and cytokines involved in this process includes thioredoxin (Trx), protein disulfide isomerase (PDI), and tumor necrosis factor (TNF) superfamilies. LÄS MER

  4. 3. THE ANGIOGENIC RESPONSE IN HYPOXIC HEART. Experimental studies in mice

    Författare :Fei Tian; Göteborgs universitet; []
    Nyckelord :hypoxia; angiogenesis; mice; endoglin; SUMO; PDI;

    Sammanfattning : Coronary artery disease is the leading cause of death in the western world today. Although induction of angiogenesis would appear to be an ideal therapeutic strategy, clinical trials of proangiogenic factors have proved disappointing. LÄS MER

  5. 4. Characterization of ERp29 : a novel secretion factor of endoplasmic reticulum

    Författare :Ernest Sargsyan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : ERp29 is a ubiquitously expressed endoplasmic reticulum protein strongly conserved in mammalian species. The N-terminal domain of ERp29 is similar to the thioredoxin domain of protein disulfide isomerase (PDI) lacking however the double-cysteine active site motif. The C-terminal domain is a novel five-helical fold. LÄS MER

  7. 5. The assembly and secretion of ApoB containing lipoproteins

    Författare :Pia Stillemark; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Apolipoprotein B; lipoprotein; VLDL; microsomal triglyceride transfer protein; chaperone;

    Sammanfattning : Increased levels of cholesterol and triglycerides in the blood are important risk factors for the development of premature atherosclerosis and its complications such as coronary-heart diseases, stroke and peripheral vascular diseases. These diseases are the major causes of death in Europe, USA and part of Asia. LÄS MER