Sökning: "Protein quality control PQC"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden Protein quality control PQC.

  1. 1. On chaperone co-operation in temporal and spatial protein quality control

    Författare :Rebecca Andersson; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular chaperones; Heat shock proteins; Hsp70 chaperones; Proteostasis; Ageing; Asymmetric damage segregation; Peroxiredoxins; Spatial protein quality control;

    Sammanfattning : In order for a protein to be able to function correctly it needs to adopt its proper fold. Because of this, protein quality control (PQC) is vital at every level of cellular function. The central protein in PQC networks across all kingdoms of life are the Hsp70 molecular chaperones. LÄS MER

  3. 2. Interconnectivity of mitochondrial protein biogenesis and homeostasis

    Författare :Carmela Vázquez Calvo; Martin Ott; Jan Riemer; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mitochondria; proteostasis; protein quality control; chaperones; biokemi; Biochemistry;

    Sammanfattning : To ensure correct protein function, the cells are equipped with a tightly regulated network of chaperones that support protein folding and actively participate in protein quality control (PQC) and turnover. Due to the dual origin of the mitochondrial proteome, the cytosolic and mitochondrial PQC networks coordinate to ensure protein import and assembly in the organelle. LÄS MER

  4. 3. Damage Segregation and Cellular Rejuvenation in Saccharomyces cerevisiae

    Författare :Sandra Malmgren Hill; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Aging; protein damage; quality control; metacaspase; aggregates; segregation; vacuole;

    Sammanfattning : The process of aging is defined as a time-dependent decline in cellular functionality, and aging is thought to have evolved as organisms were optimized for reproduction, at the cost of an imperfect repair and maintenance system. As a consequence, different kinds of dysfunctional components and damage accumulate over time. LÄS MER

  5. 4. Regulation of Hsp70 function by nucleotide-exchange factors

    Författare :Naveen Kumar Chandappa Gowda; Claes Andréasson; Gary Jones; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Heat shock proteins Hsps ; Hsp70; Molecular chaperones; Nucleotide-exchange factors NEFs ; Protein quality control PQC ; Proteostasis; Ubiquitin-proteasome system; Cell Biology; cellbiologi;

    Sammanfattning : Protein folding is the process in which polypeptides in their non-native states attain the unique folds of their native states. Adverse environmental conditions and genetic predisposition challenge the folding process and accelerate the production of proteotoxic misfolded proteins. LÄS MER

  7. 5. Functional details of human HtrA2 protease studied by NMR spectroscopy

    Författare :Emelie E. Aspholm; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; HtrA2; nuclear magnetic resonance; protein quality control; neurodegenerative disease; apoptosis;

    Sammanfattning : Cells rely on an array of cellular machineries in the protein quality control system (PQC) to maintain the health of the collective proteome. The HtrA family of serine proteases are found in all kingdoms of life and function in the PQC by degrading damaged and aggregated proteins as well as by acting as molecular chaperones. LÄS MER