Sökning: "Protein aggregate"

Visar resultat 16 - 20 av 88 avhandlingar innehållade orden Protein aggregate.

1. 16. Anionic oligothiophenes : Optical tools for multimodal fluorescent assignment of protein aggregates

   Författare :Rozalyn Simon; Peter Nilsson; Sara Snogerup Linse; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : Luminescent conjugated oligothiophenes (LCOs) represent a useful and interesting class of materials well known for their abilities as transducers for colorimetric and fluorometric reporting. Specifically, they have the ability to produce a conformation-dependent spectral signature reflective of changes in their local environment. LÄS MER

3. 17. Processing, stability and interactions of lung surfactant protein C

   Författare :Jing Li; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Mature SP-C is a 4.2 kDa transmembrane protein which is uniquely expressed in the alveolar type II cell. Human SP-C is generated via multistep proteolytic cleavage of both the C-terminal and Nterminal regions of proSP-C. LÄS MER

4. 18. Luminescent molecular recognition of pathognomonic and aging associated protein aggregates

   Författare :Daniel Sjölander; Per Hammarström; Peter Nilsson; Uno Carlsson; Jan Johansson; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : Various protein inclusions have been recognized to be associated with aging and pathogenic conditions, such as in Alzheimer’s disease, Parkinson’s disease, Type 2 diabetes, and the prionoses Creutzfeldt-Jakob disease, Chronic wasting disease (CWD), and Mad cow disease. The causative transition of protein aggregation is the alteration in the conformation of the protein that renders the protein susceptible towards self-assembly. LÄS MER

5. 19. Nanostructure and biomolecule interactions : Characterizing the complex

   Författare :Stefan Gunnarsson; NanoLund: Centre for Nanoscience; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Nanostructures; Proteins; Lipids; Protein corona; Aggregation; Sedimentation; Diffusion; Electron microscopy; Enzyme activity; Nanowires; Nanoparticles;

   Sammanfattning : This thesis presents the results of studies done on various biomolecules and their interactions with nanomaterials. The biomolecule sources are everything from purified, single proteins to the complicated mixture of blood serum and cell culture media. LÄS MER

7. 20. Structural investigation of SOD1 aggregates in ALS : identification of prion strains using anti-peptide antibodies

   Författare :Johan Bergh; Thomas Brännström; Stefan L. Marklund; Peter M. Andersen; Joakim Bergström; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS; SOD1; prion; motor neuron disease; neurodegeneration; strain; seeding; protein aggregation; transgenic mice; peptide antibodies; Neurology; neurologi;

   Sammanfattning : Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative syndrome characterized by progressive degeneration of motor neurons that result in muscle wasting. The symptoms advance gradually to paralysis and eventually death. Most patients suffer from sporadic ALS (sALS) but 10% report a familial predisposition. LÄS MER