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1. Properties of Protein and Polymer Systems
Sammanfattning : Interactions of proteins with other proteins, with polymers and with surfaces are of great practical importance within for instance protein purification, drug delivery, and food technology. The aim of this work is to increase the understanding of protein-protein, protein-polyelectrolyte, and protein-surface interactions, particularly concerning the role of electrostatic interactions in these systems. LÄS MER
2. On the role of actin in yeast protein quality control
Sammanfattning : Every cell is equipped with a protein quality control system to ensure the proper function of proteins. This is essential for both cell maintenance and the generation of new and healthy cells. LÄS MER
3. Fluorescent Probes and Protein Misfolding: Methods and Applications
Sammanfattning : Protein misfolding is a frequently occurring event in living cells and without the quality control, the consequences are disasterous. In this thesis, we studied protein misfolding in vitro by employing a variety of fluorophores, to either detect the highly ordered aggregates of intrinsically disordered proteins/peptides or slight misfolding of a natively folded protein. LÄS MER
4. Calcium-dependent Affinity Domains for the Purification of Antibodies and Antibody Fragments
Sammanfattning : Antibodies are essential proteins in both our bodies and biotechnological research, and hold outstanding therapeutic value. The market for antibody-based therapeutics has grown exponentially during the last decades, owing to several advantages over small molecule drugs, such as fewer undesirable side effects associated with a higher target specificity. LÄS MER
5. Stress response regulation and protein aggregate inheritance in Caulobacter crescentus
Sammanfattning : Many stress conditions a cell encounters threaten the continuation of basic biological processes ultimately endangering its survival. Heat shock and antibiotic exposure can lead to a sudden surge of protein un- and misfolding, while nutrient starvation directly causes a lack of energy and molecular building blocks. LÄS MER