Sökning: "Protein accumulation"

Visar resultat 1 - 5 av 587 avhandlingar innehållade orden Protein accumulation.

  1. 1. Angiopoietin-like protein 4 : an unfolding chaperone regulating lipoprotein lipase activity

    Författare :Valentina Sukonina; Gunilla Olivecrona; Lena Kjellen; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lipoprotein lipase; angiopoietin-like protein 4; protein folding; human adipose tissue; macrophages; peroxisome proliferator-activated receptor delta PPARδ ; Medical microbiology; Medicinsk mikrobiologi;

    Sammanfattning : Lipoprotein lipase (LPL) is the main enzyme hydrolyzing triglyceride-rich lipoproteins in plasma. Proteoglycan-bound LPL on the vascular endothelium represent the functional pool of active enzyme. LPL is regulated in a tissue specific manner according to metabolic demands. LÄS MER

  3. 2. Metal Affinity Peptides in Biotechnological Applications As tools in protein purification, protein stabilisation, metal quantification and metal tolerance of bacteria and plants

    Författare :Malin Mejàre; Tillämpad biokemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cadmium; metal quantification; fusion tag; metal affinity tag; phage display; peptide library; metal tolerance; metal resistance; metal accumulation; bioremediation; transgenic plant; tobacco; potato; protein purification; immobilised metal affinity chromatography; metal affinity precipitation; metal detection; protein stabilisation; Bioteknik; Biotechnology; Biokemi; Metabolism; Biochemistry; metal ion;

    Sammanfattning : Metal affinity tags have been fused to proteins and demonstrated to function as tools in protein purification, protein stabilisation, quantitative metal analysis and metal tolerance of bacteria and plants. In biotechnological applications proteins frequently have to function in nonnatural environments with harsh conditions which impose requirements for high stability on the proteins. LÄS MER

  4. 3. Nutritional Limitations of a Green Protein Shift with Focus on Iron

    Författare :Cecilia Mayer Labba; Chalmers tekniska högskola; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; phytate; non-heme iron absorption; antinutrients; protein shift; protein extract; meat substitutes; plant-based; fava bean; zinc bioavailability; iron bioavailability; sustainable nutrition;

    Sammanfattning : A dietary shift into plant-based diets (PBD) to reduce the climate footprint is advocated. Effects on nutrition and health from a modern PBD, composed of replacement products based on protein extracts are however currently unknown. LÄS MER

  5. 4. Arsenic-induced protein aggregation and toxicity in Saccharomyces cerevisiae

    Författare :Sansan Hua; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Arsenic; Protein aggregation; Protein quality control; Yeast;

    Sammanfattning : Arsenic is prevalent in the environment and this toxic metalloid poses a substantial threat to human health with 100-200 million people worldwide estimated to be at risk. Chronic exposure to arsenic is associated with neurodegenerative and age-related disorders that are characterized by the accumulation of protein aggregates, including Parkinson’s and Alzheimer’s disease. LÄS MER

  7. 5. Transthyretin and the transthyretin-related protein: A structural study

    Författare :Erik Lundberg; A. Elisabeth Sauer-Eriksson; Lennart Sjölin; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Transthyretin; Transthyretin-related protein; X-ray crystallography; Protein structure; Amyloidosis; Structural biology; Strukturbiologi;

    Sammanfattning : Transthyretin (TTR) is one of several proteins involved in amyloid disease in humans. Unknown conformational changes of the native state of TTR result in aggregation of TTR molecules into amyloid fibrils, which accumulate in extracellular tissues. This may result in different clinical symptoms, e.g. LÄS MER