Avancerad sökning
Visar resultat 1 - 5 av 25 avhandlingar som matchar ovanstående sökkriterier.
1. Protein Damage Control during Embryonic Stem Cell Differentiation: Role of the Proteasome
Sammanfattning : During the lifespan of organisms ranging from yeast to humans, there is an accumulation of macromolecular damage. However, these organisms produce youthful progeny with low damage levels. This thesis focuses on how this is accomplished. LÄS MER
2. The Path to Destruction : Understanding the mechanism and regulation of proteasomal degradation
Sammanfattning : A majority of intracellular proteins are degraded by the ubiquitin proteasome system (UPS). In this thesis, both the mechanism of the degradation and the regulation of UPS have been investigated. The importance of the p97 ATPase for proteasomal degradation of cytosolic substrates was examined. LÄS MER
3. On Aging, Behavior and the Role of PA28αβ in Protein Homeostasis
Sammanfattning : As life expectancy increases, understanding challenges related to the processes of aging are more relevant than ever. Common age-related diseases progress as consequences of accumulative protein damage and protein aggregates. LÄS MER
4. The role of the ubiquitin-proteasome system in neurodegenerative disorders
Sammanfattning : Neurodegenerative disorders are a heterogeneous group of clinically and pathologically diverse diseases. The diseases are characterised by selective loss of neurons. in specific regions of the brain. The result is disruption of motor, sensory or cognitive systems, leading to severe disability of the patients. LÄS MER
5. Effects of proteasome inhibitors on chondrogenesis and linear bone growth
Sammanfattning : Linear bone growth occurs at the growth plate, a thin layer of cartilage between the epiphysis and metaphysis of long bones. In the growth plate, resting/stem-like chondrocytes divide and generate the highly proliferative chondrocytes, which further differentiate into the enlarged hypertrophic form before being substituted by bone, a process called endochondral ossification. LÄS MER