Sökning: "Prostate-specific membrane antigen PSMA"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Prostate-specific membrane antigen PSMA.

1. 1. Theranostic Targeting of GRPR and PSMA in Prostate Cancer

   Författare :Ayman Abouzayed; Anna Orlova; Ulrika Rosenström; Anzhelika Vorobyeva; Bogdan Mitran; Cristina Müller; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prostate cancer; gastrin-releasing peptide receptor GRPR ; prostate-specific membrane antigen PSMA ; nuclear medicine; molecular imaging; radiotracers; theranostics; Farmaceutisk vetenskap; Pharmaceutical Science; Oncology; Onkologi;

   Sammanfattning : This thesis is based on five original articles that investigated the theranostics of prostate cancer by gastrin-releasing peptide receptor (GRPR) and prostate-specific membrane antigen (PSMA) targeting. GRPR and PSMA are two extensively evaluated prostate cancer cell markers due to their overexpression in the majority of prostate cancer samples. LÄS MER

3. 2. Prostate cancer theranostics using GRPR antagonist RM26

   Författare :Bogdan Mitran; Anna Orlova; Vladimir Tolmachev; Ulrika Rosenström; Tony Lahoutte; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gastrin-releasing peptide receptor GRPR ; Bombesin; Prostate-specific membrane antigen PSMA ; Antagonist; Radionuclide molecular imaging; Theranostics; Peptide receptor radionuclide therapy PRRT .;

   Sammanfattning : The malignant transformation of cells is often associated with an alteration of their molecular phenotype, resulting in overexpression of several cell surface proteins. Gastrin-releasing peptide receptor (GRPR) and prostate-specific membrane antigen (PSMA) are examples of such pro-teins that are expressed at a high density in prostate cancer. LÄS MER

4. 3. PET and MR imaging in prostate cancer

   Författare :Kristina Sandgren; Tufve Nyholm; Joakim Jonsson; Camilla Thellenberg-Karlsson; Lennart Blomqvist; Heidi Lyng; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PET; PSMA; MRI; PET MRI; imaging; prostate cancer; intraprostatic tumour detection; radiofysik; radiation physics;

   Sammanfattning : The current risk assessment of prostate cancer (PC) relies on histopathological samples from biopsies and clinical variables such as prostate-specific antigen (PSA). However, this comes with uncertainties and in some cases it can be challenging to separate patients who would benefit from radical treatment and those who would not. LÄS MER

5. 4. PET in Prostate Cancer – Detection, Tumour Biology and Prognosis

   Författare :Naresh Kumar Regula; Jens Sörensen; Mark Lubberink; Irina Velikyan; Katrine Riklund; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; 11C-acetate; 68Ga-PSMA-11; 18F-NaF; PET CT; Radiology; Radiologi;

   Sammanfattning : Prostate cancer (PCa) is the most common non-cutaneous malignancy in men and the leading cause of cancer-related deaths in Sweden. Despite the major advances, the current diagnostic modalities fall short of standards, specifically, precise localization required for effective management of the PCa. LÄS MER

7. 5. Aspects of PET-CT in prostate cancer. Protocol optimization, diagnostic accuracy, and dosimetry

   Författare :Mimmi Bjöersdorff; Malmö Nuklearmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PET-CT; Prostatacancer; [18F]FCH; [18F]PSMA-1007; optimering; diagnostisk noggrannhet; dosimetri; PET-CT; Prostate Cancer; [18F]FCH; [18F]PSMA-1007; Optimization; Diagnostic accuracy; Dosimetric;

   Sammanfattning : The PET-CT imaging modality is based on positron emission tomography combined with computed tomography. Before a PET-CT examination, a radioactive tracer (also called a radiopharmaceutical) is intravenously injected into the patient. PET technology images the distribution of this tracer element by detecting the decay. LÄS MER