Sökning: "Proof-of-concept"

Visar resultat 1 - 5 av 259 avhandlingar innehållade ordet Proof-of-concept.

1. 1. Antibody- and Peptide-based Immunotherapies : Proof-of-concept and safety considerations

   Författare :Erika Fletcher; Sara Mangsbo; Vivianne Malmström; Uppsala universitet; []
   Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immune complex; conjugat; vaccine; CD40; whole blood; cytokine release syndrome; Immunologi; Immunology;

   Sammanfattning : The aim of cancer immunotherapy is to eradicate tumours by inducing a tumour-specific immune response. This thesis focuses on how antibodies and peptides can improve antigen presentation and the subsequent tumour-specific T cell response. Tumour recognition by the immune system can be promoted through delivery of antigen in the form of a vaccine. LÄS MER

3. 2. Massive MIMO: Prototyping, Proof-of-Concept and Implementation

   Författare :Steffen Malkowsky; Institutionen för elektro- och informationsteknik; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Massive MIMO; Testbed Design; Prototyping; ASIP; Processor;

   Sammanfattning : Wireless communication is evolving rapidly with ever more connected devicesand significantly increasing data rates. Since the invention of the smartphoneand the mass introduction of mobile apps, users demand more andmore traffic to stream music, watch high-definition video or to simply browsethe internet. LÄS MER

4. 3. Model-Based Optimization of Clinical Trial Designs

   Författare :Camille Vong; Mats O. Karlsson; Andrew C. Hooker; Lena E. Friberg; Marylore Chenel; Oliver Sander; Uppsala universitet; []
   Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonlinear mixed-effects models; pharmacometrics; likelihood ratio test; NONMEM; power; sample size; study design; proof-of-concept; dose-finding; population optimal design; LOQ; BQL data; neutropenia; docetaxel; myelosuppression; thrombocytopenia; MTD; Bayesian methods; 3 3 algorithm; dose escalation study; Pharmaceutical Science; Farmaceutisk vetenskap;

   Sammanfattning : General attrition rates in drug development pipeline have been recognized as a necessity to shift gears towards new methodologies that allow earlier and correct decisions, and the optimal use of all information accrued throughout the process. The quantitative science of pharmacometrics using pharmacokinetic-pharmacodynamic models was identified as one of the strategies core to this renaissance. LÄS MER

5. 4. Environmental Technology and its Role in the Search for Urban Environmental Sustainability : The Dynamics of Adaptation

   Författare :Santiago Mejía-Dugand; Olof Hejlm; Leenard Baas; Julio Dávila; Linköpings universitet; []
   Nyckelord :AGRICULTURAL SCIENCES; LANTBRUKSVETENSKAPER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Technology Adaptation; Governance Mechanisms; Spread of Technology; Stakeholder Involvement; Proof-of-concept; Environmental Technology Suppliers; Urban Imaginaries;

   Sammanfattning : The aim of this thesis is to analyze the role that environmental technology plays in the solution of environmental problems in cities, and discuss models and conditions that can facilitate the processes of selection, implementation and use of environmental technologies in and by cities.The technological component is perhaps one of the most important characteristics of modern cities. LÄS MER

7. 5. Technological Advancements in Affinity Proteomics : From planar antibody microarrays towards a solution-based platform

   Författare :Mattias Brofelth; Institutionen för immunteknologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Affinity proteomics; Antibody microarrays; scFv; Biomarkers; MIAS;

   Sammanfattning : Abstract: Proteomics has the potential to deliver disease-associated biomarkers that could provide diagnostic, prognostic and predictive information to enable precision medicine. Affinity proteomics, most commonly based on antibodies and their ability to specifically capture target proteins, has emerged has a valuable tool in biomarker discovery. LÄS MER