Sökning: "Principal"

Visar resultat 16 - 20 av 1197 avhandlingar innehållade ordet Principal.

  1. 16. Mapping the Huntington's disease process using cerebrospinal fluid analysis

    Författare :Valter Niemelä; Anne-Marie Landtblom; Dag Nyholm; Jimmy Sundblom; Edward Wild; Uppsala universitet; []
    Nyckelord :Neurodegeneration; Huntingtons disease; Neurogenetics; Neuroinflammation; Neurofilament light; tau; Proenkephalin; Neurology; Neurologi;

    Sammanfattning : Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder, caused by a CAG-repeat expansion in the HTT-gene. Today there are no disease-modifying therapies (DMTs), but several promising clinical trials are underway, including therapies that reduce mutant huntingtin expression. LÄS MER

  3. 17. Norovirus and rotavirus susceptibility : studies from a Nicaraguan birth cohort

    Författare :Yaoska Reyes; Johan Nordgren; Lennart Svensson; Miren Iturriza-Gómara; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Norovirus; Rotavirus; Birth cohort; Gastroenteritis; Incidence; Children; Secretor; Immune response.;

    Sammanfattning : Norovirus and rotavirus are major causes of pediatric acute gastroenteritis (AGE). It is estimated that norovirus is responsible for ~20% of all diarrheal diseases in children worldwide and causes approximately 200,000 deaths each year, mostly in young children and the elderly. LÄS MER

  4. 18. Enhancing the therapeutic effect of biological drugs with protein engineering : Focusing on pre-clinical Alzheimer’s disease therapy

    Författare :Fadi Rofo; Greta Hultqvist; Stina Syvänen; Sara Mangsbo; Joy Zuchero; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; amyloid-beta; blood-brain barrier; transferrin receptor; protein-drugs; multivalent-bispecific antibodies;

    Sammanfattning : Aggregation of the amyloid-β peptide (Aβ) is one of the main pathological hallmarks in Alzheimer’s disease (AD). The soluble Aβ aggregates (oligomers and protofibrils) have shown to be the most harmful species. Hence, targeting these aggregates can be of therapeutic potential. LÄS MER

  5. 19. A Composable and Extensible Environment for Equation-based Modeling and Simulation of Variable Structured Systems in Modelica

    Författare :John Tinnerholm; Adrian Pop; Martin Sjölund; Peter Fritzson; Christopher Rackauckas; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Modeling and Simulation are usually used to solve real-world problems safely and efficiently by constructing digital models of Cyber-Physical Systems. The models can be simulated and analyzed with respect to requirements, and decisions about their design can be based on this analysis. LÄS MER

  7. 20. Workplace Social Relations in the Return-to-Work process

    Författare :Åsa Tjulin; Kerstin Ekberg; Elinor Edvardsson Stiwne; William Shaw; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Public health medicine research areas; Folkhälsomedicinska forskningsområden;

    Sammanfattning : The overall aim of this thesis was to explore the impact of workplace social relations on the implementation of return-to-work interventions. The thesis consists of four separate papers with specific aims. LÄS MER