Sökning: "Primary immunodeficiency"
Visar resultat 6 - 10 av 67 avhandlingar innehållade orden Primary immunodeficiency.
6. Functional analysis of ATM with relevance for primary immunodeficiency and tumor formation
Sammanfattning : Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by cerebellar degeneration with ataxia, ocular and cutaneous telangiectasias, radiosensitivity, chromosomal instability, immunodeficiency, and cancer predisposition in both patients and heterozygous carriers of the gene. The gene responsible for the disorder, ATM, has been identified as a member of a family of phosphatidylinositol 3-kinaserelated genes and is one of the master controllers of the networks that are involved in cell cycle control and response to DNA damage. LÄS MER
7. Germinal centers : why and why not? The humoral response in primary immunodeficiency
Sammanfattning : An efficient and regulated immune system is required for protection against pathogens. B cells are required for a humoral response. For a sustained humoral response against pathogens germinal center (GC) reactions are required. In the GC reaction, B cells with antigen-specific B cell receptors are selected and expanded. LÄS MER
8. Novel genetic associations with common variable immunodeficiency
Sammanfattning : Common variable immunodeficiency (CVID) is the most frequently encountered primary immunodeficiency disorder in clinical practice and is a cause of significant morbidity and mortality for patients. The main clinical features are hypogammaglobulinemia, recurrent infections and autoimmune disorders. LÄS MER
9. Learning from primary immunodeficiencies to treat cancer
Sammanfattning : The immune system is a fine-tuned network of cells, tissues, organs and biological processes working together in order to protect our body. Immunodeficiency disorders occur when the body’s immune system is reduced or absent and can be characterized as primary, if the cause of disease is genetic; or secondary, if the cause of disease are extrinsic factors. LÄS MER
10. Combination chemotherapy for human immunodeficiency virus infection
Sammanfattning : The worldwide spread of human immunodeficiency virus (HIV) has spurred the search for effective drugs to combat this deadly virus. The limited effect of monotherapy treatment, in large measure due to the development of drug resistant viral strains, has led to increased emphasis on combination chemotherapy for the treatment of HIV, the focus of this study. LÄS MER
