Sökning: "Primary immunodeficiency"

Visar resultat 16 - 20 av 67 avhandlingar innehållade orden Primary immunodeficiency.

  1. 16. NGS based studies on primary immunodeficiencies (PIDs) : causative gene identification, tool development and application

    Författare :Mingyan Fang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Primary immunodeficiency diseases (PIDs) are composed by a group of highly heterogeneous immune system diseases, of which approximately 350 forms of PID have been described so far. The causative gene of around 60% of patients with PIDs has yet unknown. LÄS MER

  3. 17. Immunoglobulins, immunoglobulin subclass-distributions and serologic markers in some renal and systemic disorders

    Författare :Gabriel Almroth; Jan Björklander; Linköpings universitet; []
    Nyckelord :Immunoglobulins; immunoglobulin-subclass distribution; hydralazine; ANCA; anti-:MPO; primary SjOgren s syndrome; hepatitis B vaccination; anti-HBssubclasses; immunoadsorption; plasmapheresis; antibodies; hepatitis C virus; transmission; recombinant immunoblot assay; hepatitis C genotype; MEDICINE; MEDICIN;

    Sammanfattning : In this study we evaluated pathogenetic factors and possible mediators of renal and systemic disorders where immunologic mechanisms might be of importance.An abberant immunoglobulin and IgG-subclass distribution was detected in 103 patients with primary and secondary glomerulonephritis as well as in 38 patients with the systemic disease primary Sjögren 's syndrome or purpura hypergammaglobulinemica (elevated IgG1 and low IgG2 ). LÄS MER

  4. 18. Characterisation of CD8 T cells in mucosa associated lymphoid tissue : implications for immune control of HIV-1 infection

    Författare :Máire Quigley; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :CD8 T cells; Human Immunodeficiency Virus-1; Mucosa Associated Lymphoid Tissue; perforin; cytotoxicity; gastrointestinal mucosa; tonsil; CD7 expression; Simian Immunodeficiency Virus.;

    Sammanfattning : The role of CD8 T cells has been implicated in the partial immune control of HIV-1 infection. Ultimately these cells fail to control the infection and immune deficiency ensues in the absence of antiretroviral therapy. LÄS MER

  5. 19. Molecular diagnosis of infection with Toxoplasma gondii in immunocompromised patients

    Författare :Benjamin Edvinsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Toxoplasma gondii; toxoplasmosis; transplantation; human immunodeficiency virus; polymerase chain reaction; internal amplification control; oligochromatography; Pyrosequencing;

    Sammanfattning : The protozoan parasite Toxoplasma gondii infects more than a billion people worldwide. The parasite is generally divided into three clonal lineages, denoted type I, II and III. LÄS MER

  7. 20. Molecular dissection of B-lymphocyte signalling using expression profiling

    Författare :Jessica M Lindvall; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Btk; B-lymphocyte; gene expression profiling; signal transduction;

    Sammanfattning : Gene expression profiling and bioinformatics have emerged into playing a large and diverse role in many aspects of both the clinical and molecular research. These two approaches have in this thesis work been used in combination in order to shed light to the role of Bruton's tyrosine kinase (Btk) in B-lymphocyte development and signal transduction. LÄS MER