Sökning: "Presequence Protease"

Hittade 4 avhandlingar innehållade orden Presequence Protease.

1. 1. Functional and structural studies of the Presequence protease, PreP

   Författare :Hans G Bäckman; Elzbieta Glaser; Per Gardeström; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Presequence Protease; PreP; AtPreP; hPreP; Biochemistry; biokemi;

   Sammanfattning : AtPreP (Arabidopsis thaliana Presequence Protease) is a zink metallooligopeptidase that is dually targeted to both mitochondria and chloroplasts. In these organelles it functions as a peptidasome that degrades the N-terminal targeting peptides that are cleaved off from the mature protein after protein import, as well as other unstructured peptides. LÄS MER

3. 2. Mitochondria in Alzheimer's Disease : The Presequence Protease and Mitochondria-Associated ER Membranes

   Författare :Catarina Moreira Pinho; Elzbieta Glaser; Paolo Bernardi; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Alzheimer s Disease; Mitochondria; Mitochondria-associated ER membranes; human Presequence Protease; Biochemistry; biokemi;

   Sammanfattning : Alzheimer’s disease (AD) is one of the most prevalent age-related neurodegenerative disorders and the accumulation of the amyloid-β peptide (Aβ) in the temporal lobe has been implicated in the pathology of AD. Synaptic transmission in neuronal cells is a highly energy dependent process, which relies on the presence and proper function of mitochondria. LÄS MER

4. 3. The Mitochondrial Peptidasome, PreP, relation to Alzheimer Disease

   Författare :Nyosha Alikhani; Elzbieta Glaser; Doron Rapaport; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Biokemi; Biochemistry; biokemi;

   Sammanfattning : Amyloid-β (Aβ) is the toxic peptide implicated in the pathogenesis of Alzheimer Disease (AD). Accumulation of Aβ has been shown in brain mitochondria from AD patients and AD mice models. The occurrence of Aβ in the mitochondrial matrix leads to free radical generation and apoptosis in neurons. LÄS MER

5. 4. Dual Targeting of Proteins to Mitochondria and Chloroplasts

   Författare :Anna-Karin Berglund; Elzbieta Glaser; Ophry Pines; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Biokemi; Biochemistry; biokemi;

   Sammanfattning : The vast majority of mitochondrial and chloroplastic proteins are nuclear encoded, synthesized in the cytosol and imported into the respective organelle using an N-terminal extension, the targeting peptide (TP). After import into the organelle, the TP is cleaved off and degraded by the Presequence protease (PreP). LÄS MER