Sökning: "Premature senescence"

Visar resultat 1 - 5 av 15 avhandlingar innehållade orden Premature senescence.

  1. 1. Short and long-term effects of exposure to low dose and low dose rate of gamma radiation : using in vitro and in vivo models

    Författare :Traimate Sangsuwan; Siamak Haghdoost; Eva Forssell-Aronsson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Low dose; Low dose rate; High dose rate; Ionizing radiation; Adaptive response; Senescence; Premature senescence; Oxidative stress; Drosophila embryo; Mutation; DNA repair; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Assessment of human health risks from exposure to ionizing radiation (IR) is mainly based on the extrapolation of results from epidemiological studies on populations exposed to relatively high doses and often at high dose rates (HDR). Risk estimates after exposure to low doses and in particular at low dose rates (LDR) remain controversial due to a lack of epidemiological evidence. LÄS MER

  3. 2. Novel radiation targets in the endothelium and heart muscle

    Författare :Venkata Ramesh Yentrapalli; Siamak Haghdoost; William F. Morgan; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ionizing radiation; Endothelial cells; Senescence; Cardiovascular disease; Proteomics; molekylärgenetik; Molecular Genetics;

    Sammanfattning : Worldwide, people are being exposed to natural and man-made sources of radiation. Epidemiological studies have shown an increased risk of vascular diseases in populations that have been exposed to ionizing radiation. Vascular endothelium is implicated as one of the targets for radiation leading to the development of cardiovascular diseases. LÄS MER

  4. 3. Optimizing experimental radioimmunotherapy : investigating the different mechanisms behind radiation induced cell deaths

    Författare :Theres Lindgren; David Eriksson; Torgny Stigbrand; Bo Stenerlöw; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mitotic catastrophe; senescence; cell cycle checkpoint; apoptosis; radiation; gene expression; p53; immunologi; Immunology; radiofysik; radiation physics;

    Sammanfattning : Background. Radiation therapy is an important treatment regimen for malignant disease. Radiation therapy uses ionizing radiation to induce DNA damage in tumor cells in order to kill them. LÄS MER

  5. 4. Mechanism behind the development of radiation-induced cardiovascular effects

    Författare :Venkata Ramesh Yentrapalli; Siamak Haghdoost; Andrzej Wojcik; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; molekylärgenetik; Molecular Genetics;

    Sammanfattning : Epidemiological studies on acutely and chronically exposed individuals indicate that ionising radiation could be a risk factor for cardiovascular diseases. Experimental data regarding radiation-induced cardiovascular late effects are limited and biological mechanisms behind these late effects are still unclear. LÄS MER

  7. 5. Metalloproteinases in development and disease

    Författare :Zhongjun Zhou; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Metalloproteinases are Zn-dependent proteases composed of five superfamilies. One important subfamily is the matrix metalloproteinases (MMPs) that process various components of the extracellular matrix (ECM) and non-ECM proteins. LÄS MER