Sökning: "Preformed fibrils"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden Preformed fibrils.

  1. 1. Role of Neuroinflammation in Parkinson's Disease and Related Disorders

    Författare :Edoardo Brandi; Neural plasticitet och reparation; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alpha synuclein; Preformed fibrils; Microglia; Astrocyte; Neuroinflammation; Lipopolysaccharides; Parkinson Disease; Lewy Body Dementia; Multiple system atrophy; Synucleinopathies;

    Sammanfattning : Synucleinopathies are neurodegenerative disorders characterized by intracellular protein aggregates, progressive neurodegeneration, and neuroinflammation. Alpha-synuclein (a-syn) is the principal component of intracellular aggregates and can be modified by several mutations and post-translational modifications (PTMs), which can alter the protein structure affecting its aggregation, toxicity, and ability to spread. LÄS MER

  3. 2. Synthesis and characterization of fluorescent stilbene-based probes targeting amyloid fibrils

    Författare :Jun Zhang; Peter Konradsson; Per Hammarström; Xiongyu Wu; Lin Li; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Alzheimer’s disease (AD) is characterized by two main protein aggregate hallmarks in the brain: extracellular deposition of the amyloid-β (Aβ) in senile plaques and intracellular neurofibrillary tangles (NFTs) consisting of hyperphosphorylated tau protein. The past decade has seen great progress in the development of imaging probes for the non-invasive detection of Aβ and tau aggregates. LÄS MER

  4. 3. Medin amyloid - a matter close to the heart : Studies on medin amyloid formation and involvement in aortic pathology

    Författare :Annika Larsson; Per Westermark; Sari Kiuru-Enari; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AA amyloidosis; aging; amyloid; aneurysm; arterial media; dissection; elastin; medin amyloid; lactadherin; thoracic aorta; Pathology; Patologi;

    Sammanfattning : Amyloidoses are a group of protein misfolding diseases characterized by deposits of insoluble fibrillar protein aggregates. Medin amyloid, which is the focus of this thesis, appears in the media of the thoracic aorta in nearly all individuals over 50 years. LÄS MER

  5. 4. Characterization of the Alzheimer's disease-associated clac protein

    Författare :Linda Söderberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer's disease (AD) is the most prevalent form of dementia in elderly people and is neuropathologically characterized by the presence of extracellular senile plaques (SPs) in the brain. SPs are mainly composed of the amyloid beta-peptide (Abeta), proteolytically derived from the amyloid beta-precursor protein by sequential cleavages performed by beta- and gammasecretase, to generate Abeta species of 40 and 42 amino acids, respectively. LÄS MER

  7. 5. Orientation of elongated particles in shear and extensional flow

    Författare :Karl Håkansson; Daniel Söderberg; Mats Nigam; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

    Sammanfattning : Elongated particles in fluid flows are a big part of the world we are living in. Gaining knowledge on how particles behave in different fluid flows can potentially increase the efficiency of industrial processes and decrease the world's energy consumption as well as improve the properties of future materials. LÄS MER